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Rana alergijska reakcija na metilprednizolon sa tolerancijom drugih kortikosteroida

dc.creatorAtanasković-Marković, Marina
dc.creatorGavrović-Jankulović, Marija
dc.creatorJanković, Srđa
dc.creatorBlagojević, Gordan
dc.creatorĆirković-Veličković, Tanja
dc.creatorMilojević, Irina
dc.creatorSimić, Dušica
dc.creatorNestorovic, Branimir
dc.date.accessioned2021-02-18T10:38:12Z
dc.date.available2021-02-18T10:38:12Z
dc.date.issued2012
dc.identifier.issn0370-8179
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/342
dc.description.abstractIntroduction. In spite of the wide usage of corticosteroids for the treatment of a plethora of diseases, sometimes they can induce immediate hypersensitivity reactions, which are however uncommon. Case Outline. We report a case of immediate allergic reaction induced by intravenous methylprednisolone given before operation for surgical repair of an arm contracture as a sequel of burns, which the child had tolerated a month before. Six weeks later the patient repeated the anaphylactic reaction during skin testing to methylprednisolone. In addition, basophile activation test with methylprednisolone (BAT) was positive. Conclusion. This case report describes a patient who experienced intraoperative anaphylaxis and anaphylactic reaction induced by skin testing. This is the first report on induction of both anaphylactic reactions by methylprednisolone in the same child. Clinical findings, positive BAT and positive skin tests with methylprednisolone imply that the child developed type-I hypersensitivity. The lack of cross-reactivity with other corticosteroids emphasizes that the reactions were caused by the steroid molecule.en
dc.description.abstractUvod. Uprkos širokoj primeni kortikosteroida u lečenju od različitih bolesti, oni ponekad mogu izazvati ranu alergijsku reakciju. Prikaz bolesnika. Kod dvanaestogodišnjeg dečaka došlo je do rane alergijske reakcije izazvane intravenskom primenom metilprednizolona neposredno pre hirurške intervencije, tačnije, korekcije kontrakture šake koja se javila kao komplikacija opekotine. Mesec dana pre pojave alergijske reakcije dete je primalo metilprednizolon i dobro ga podnosilo. Šest nedelja posle operacije ponovo se javila anafilaktička reakcija tokom kožnog testiranja metilprednizolonom. Primenjen je i test aktivacije bazofila (BAT) ovim lekom, čiji je nalaz bio pozitivan. Zaključak. Ovo je prvi prikaz dve vrste anafilaktičke reakcije izazvane metilprednizolonom kod iste osobe. Klinička slika, pozitivni nalaz BAT i pozitivne kožne probe na metilprednizolon pokazuju da se kod deteta razvio prvi tip hipersenzitivne reakcije. Nedostatak unakrsne reaktivnosti s ostalim kortikosteroidima ukazuje na to da je alergijska reakcija izazvana steroidnim molekulom.sr
dc.publisherSrpsko lekarsko društvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172024/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceSrpski arhiv za celokupno lekarstvo
dc.subjectcorticosteroidsen
dc.subjectchildrenen
dc.subjectimmediate allergic reactionen
dc.subjecthypersensitivityen
dc.subjectmethylprednisoloneen
dc.subjectdecasr
dc.subjecthipersenzitivne reakcijesr
dc.subjectkortikosteroidisr
dc.subjectmetilprednizolonsr
dc.subjectrani tip alergijske reakcijesr
dc.titleImmediate allergic reaction to methylprednisolone with tolerance of other corticosteroidsen
dc.titleRana alergijska reakcija na metilprednizolon sa tolerancijom drugih kortikosteroidasr
dc.typearticle
dc.rights.licenseBY-NC
dc.citation.epage235
dc.citation.issue3-4
dc.citation.other140(3-4): 233-235
dc.citation.rankM23
dc.citation.spage233
dc.citation.volume140
dc.identifier.doi10.2298/SARH1204233A
dc.identifier.fulltexthttp://intor.torlakinstitut.com/bitstream/id/188/339.pdf
dc.identifier.rcubconv_39
dc.identifier.wos000304282900019
dc.type.versionpublishedVersion


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