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dc.creatorPetrušić, Vladimir
dc.creatorŽivković, Irena
dc.creatorStojanović, Marijana
dc.creatorLukić, Ivana
dc.creatorMarinković, Emilija
dc.creatorInić-Kanada, Aleksandra
dc.creatorDimitrijevic, Ljiliana
dc.date.accessioned2021-02-18T10:38:00Z
dc.date.available2021-02-18T10:38:00Z
dc.date.issued2011
dc.identifier.issn0257-277X
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/339
dc.description.abstractNatural antibodies (NAbs) are present in circulation even before the exposure to antigen and they exert various biological functions. They are polyreactive and mainly represented by immunoglobulin M (IgM), which is the first antibody produced in an ongoing immune response to infection and/or immunization. IgM is always secreted as a polymer with predominant pentameric structure, although other polymeric forms such as hexamer can be also formed. The biological functions of hexameric IgM are still not known and it is proposed that its existence as a NAb could be deleterious. However, the nature of IgM hexamers has not been investigated yet. In this paper, we have tested the expression of natural idiotope and antigenic specificities of pentameric and hexameric IgM polymers originating from sera of patients with Waldenstrom's macroglobulinemia, as well as patients suffering from recurrent urinary bacterial infections. We demonstrate that although pentameric IgM polymers can exist as natural and immune antibodies, IgM hexamers are exclusively immune and do not exist as NAbs.en
dc.publisherHumana Press Inc, Totowa
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.rightsrestrictedAccess
dc.sourceImmunologic Research
dc.subjectHexameren
dc.subjectIgMen
dc.subjectImmune antibodiesen
dc.subjectNatural antibodiesen
dc.subjectNatural idiotopeen
dc.subjectPentameren
dc.titleAntigenic specificity and expression of a natural idiotope on human pentameric and hexameric IgM polymersen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage107
dc.citation.issue1
dc.citation.other51(1): 97-107
dc.citation.rankM22
dc.citation.spage97
dc.citation.volume51
dc.identifier.doi10.1007/s12026-011-8236-8
dc.identifier.pmid21786026
dc.identifier.rcubconv_272
dc.identifier.scopus2-s2.0-80053565521
dc.identifier.wos000295479700010
dc.type.versionpublishedVersion


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