Antigenic specificity and expression of a natural idiotope on human pentameric and hexameric IgM polymers
Само за регистроване кориснике
2011
Аутори
Petrušić, VladimirŽivković, Irena
Stojanović, Marijana
Lukić, Ivana
Marinković, Emilija
Inić-Kanada, Aleksandra
Dimitrijevic, Ljiliana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Natural antibodies (NAbs) are present in circulation even before the exposure to antigen and they exert various biological functions. They are polyreactive and mainly represented by immunoglobulin M (IgM), which is the first antibody produced in an ongoing immune response to infection and/or immunization. IgM is always secreted as a polymer with predominant pentameric structure, although other polymeric forms such as hexamer can be also formed. The biological functions of hexameric IgM are still not known and it is proposed that its existence as a NAb could be deleterious. However, the nature of IgM hexamers has not been investigated yet. In this paper, we have tested the expression of natural idiotope and antigenic specificities of pentameric and hexameric IgM polymers originating from sera of patients with Waldenstrom's macroglobulinemia, as well as patients suffering from recurrent urinary bacterial infections. We demonstrate that although pentameric IgM polymers can exist as natura...l and immune antibodies, IgM hexamers are exclusively immune and do not exist as NAbs.
Кључне речи:
Hexamer / IgM / Immune antibodies / Natural antibodies / Natural idiotope / PentamerИзвор:
Immunologic Research, 2011, 51, 1, 97-107Издавач:
- Humana Press Inc, Totowa
Финансирање / пројекти:
- Алергени, антитела, ензими и мали физиолошки значајни молекули: дизајн, структура, функција и значај (RS-MESTD-Basic Research (BR or ON)-172049)
DOI: 10.1007/s12026-011-8236-8
ISSN: 0257-277X
PubMed: 21786026
WoS: 000295479700010
Scopus: 2-s2.0-80053565521
Институција/група
TorlakTY - JOUR AU - Petrušić, Vladimir AU - Živković, Irena AU - Stojanović, Marijana AU - Lukić, Ivana AU - Marinković, Emilija AU - Inić-Kanada, Aleksandra AU - Dimitrijevic, Ljiliana PY - 2011 UR - http://intor.torlakinstitut.com/handle/123456789/339 AB - Natural antibodies (NAbs) are present in circulation even before the exposure to antigen and they exert various biological functions. They are polyreactive and mainly represented by immunoglobulin M (IgM), which is the first antibody produced in an ongoing immune response to infection and/or immunization. IgM is always secreted as a polymer with predominant pentameric structure, although other polymeric forms such as hexamer can be also formed. The biological functions of hexameric IgM are still not known and it is proposed that its existence as a NAb could be deleterious. However, the nature of IgM hexamers has not been investigated yet. In this paper, we have tested the expression of natural idiotope and antigenic specificities of pentameric and hexameric IgM polymers originating from sera of patients with Waldenstrom's macroglobulinemia, as well as patients suffering from recurrent urinary bacterial infections. We demonstrate that although pentameric IgM polymers can exist as natural and immune antibodies, IgM hexamers are exclusively immune and do not exist as NAbs. PB - Humana Press Inc, Totowa T2 - Immunologic Research T1 - Antigenic specificity and expression of a natural idiotope on human pentameric and hexameric IgM polymers EP - 107 IS - 1 SP - 97 VL - 51 DO - 10.1007/s12026-011-8236-8 ER -
@article{ author = "Petrušić, Vladimir and Živković, Irena and Stojanović, Marijana and Lukić, Ivana and Marinković, Emilija and Inić-Kanada, Aleksandra and Dimitrijevic, Ljiliana", year = "2011", abstract = "Natural antibodies (NAbs) are present in circulation even before the exposure to antigen and they exert various biological functions. They are polyreactive and mainly represented by immunoglobulin M (IgM), which is the first antibody produced in an ongoing immune response to infection and/or immunization. IgM is always secreted as a polymer with predominant pentameric structure, although other polymeric forms such as hexamer can be also formed. The biological functions of hexameric IgM are still not known and it is proposed that its existence as a NAb could be deleterious. However, the nature of IgM hexamers has not been investigated yet. In this paper, we have tested the expression of natural idiotope and antigenic specificities of pentameric and hexameric IgM polymers originating from sera of patients with Waldenstrom's macroglobulinemia, as well as patients suffering from recurrent urinary bacterial infections. We demonstrate that although pentameric IgM polymers can exist as natural and immune antibodies, IgM hexamers are exclusively immune and do not exist as NAbs.", publisher = "Humana Press Inc, Totowa", journal = "Immunologic Research", title = "Antigenic specificity and expression of a natural idiotope on human pentameric and hexameric IgM polymers", pages = "107-97", number = "1", volume = "51", doi = "10.1007/s12026-011-8236-8" }
Petrušić, V., Živković, I., Stojanović, M., Lukić, I., Marinković, E., Inić-Kanada, A.,& Dimitrijevic, L.. (2011). Antigenic specificity and expression of a natural idiotope on human pentameric and hexameric IgM polymers. in Immunologic Research Humana Press Inc, Totowa., 51(1), 97-107. https://doi.org/10.1007/s12026-011-8236-8
Petrušić V, Živković I, Stojanović M, Lukić I, Marinković E, Inić-Kanada A, Dimitrijevic L. Antigenic specificity and expression of a natural idiotope on human pentameric and hexameric IgM polymers. in Immunologic Research. 2011;51(1):97-107. doi:10.1007/s12026-011-8236-8 .
Petrušić, Vladimir, Živković, Irena, Stojanović, Marijana, Lukić, Ivana, Marinković, Emilija, Inić-Kanada, Aleksandra, Dimitrijevic, Ljiliana, "Antigenic specificity and expression of a natural idiotope on human pentameric and hexameric IgM polymers" in Immunologic Research, 51, no. 1 (2011):97-107, https://doi.org/10.1007/s12026-011-8236-8 . .