Banana lectin interactions with the immune system: Implications for future therapeutic applications
Апстракт
Lectins are a highly diverse group of proteins whose biological functions have been associated with the carbohydrate binding activities. Banana lectin is a member of the jacalin-related family of lectins, and belongs to the glucose/mannose specific subgroup. However, it shows a unique specificity for internal α1,3 linkages as well as β1,3 linkages at the reducing termini in branched mannose oligosaccharides, which are components of the-core region of N-linked glycoproteins. As some other plant lectins, banana lectin is stable to the harsh conditions of the human gastrointestinal tract. As a small protein it seems to be able to pass the mucosal barrier and to reach the immune system inducing specific IgG4 antibodies. Banana lectin also displays T cell proliferation in CD3+, CD4+ and CD8+ populations of human PBMCs. It has been recently shown that in vitro stimulation of Balb/c and C57 BL/6 splenocytes by the recombinantly produced banana lectin resulted in the proliferation of T cells a...nd an increased secretion of interferon-gamma. Due to its notable immunomodulatory potential, it has been proposed for the treatment of some Th2-related disorders. This work will discuss banana lectin interactions with the immune system and consider implications for future therapeutic applications.
Извор:
Bananas: Nutrition, Diseases and Trade Issues, 2011, 307-318Издавач:
- Nova Science Publishers, Inc.
Scopus: 2-s2.0-84892341156
Институција/група
TorlakTY - CHAP AU - Gavrović-Jankulović, Marija AU - Dimitrijević, Rajna AU - Stojanović, Marijana PY - 2011 UR - http://intor.torlakinstitut.com/handle/123456789/329 AB - Lectins are a highly diverse group of proteins whose biological functions have been associated with the carbohydrate binding activities. Banana lectin is a member of the jacalin-related family of lectins, and belongs to the glucose/mannose specific subgroup. However, it shows a unique specificity for internal α1,3 linkages as well as β1,3 linkages at the reducing termini in branched mannose oligosaccharides, which are components of the-core region of N-linked glycoproteins. As some other plant lectins, banana lectin is stable to the harsh conditions of the human gastrointestinal tract. As a small protein it seems to be able to pass the mucosal barrier and to reach the immune system inducing specific IgG4 antibodies. Banana lectin also displays T cell proliferation in CD3+, CD4+ and CD8+ populations of human PBMCs. It has been recently shown that in vitro stimulation of Balb/c and C57 BL/6 splenocytes by the recombinantly produced banana lectin resulted in the proliferation of T cells and an increased secretion of interferon-gamma. Due to its notable immunomodulatory potential, it has been proposed for the treatment of some Th2-related disorders. This work will discuss banana lectin interactions with the immune system and consider implications for future therapeutic applications. PB - Nova Science Publishers, Inc. T2 - Bananas: Nutrition, Diseases and Trade Issues T1 - Banana lectin interactions with the immune system: Implications for future therapeutic applications EP - 318 SP - 307 UR - https://hdl.handle.net/21.15107/rcub_intor_329 ER -
@inbook{ author = "Gavrović-Jankulović, Marija and Dimitrijević, Rajna and Stojanović, Marijana", year = "2011", abstract = "Lectins are a highly diverse group of proteins whose biological functions have been associated with the carbohydrate binding activities. Banana lectin is a member of the jacalin-related family of lectins, and belongs to the glucose/mannose specific subgroup. However, it shows a unique specificity for internal α1,3 linkages as well as β1,3 linkages at the reducing termini in branched mannose oligosaccharides, which are components of the-core region of N-linked glycoproteins. As some other plant lectins, banana lectin is stable to the harsh conditions of the human gastrointestinal tract. As a small protein it seems to be able to pass the mucosal barrier and to reach the immune system inducing specific IgG4 antibodies. Banana lectin also displays T cell proliferation in CD3+, CD4+ and CD8+ populations of human PBMCs. It has been recently shown that in vitro stimulation of Balb/c and C57 BL/6 splenocytes by the recombinantly produced banana lectin resulted in the proliferation of T cells and an increased secretion of interferon-gamma. Due to its notable immunomodulatory potential, it has been proposed for the treatment of some Th2-related disorders. This work will discuss banana lectin interactions with the immune system and consider implications for future therapeutic applications.", publisher = "Nova Science Publishers, Inc.", journal = "Bananas: Nutrition, Diseases and Trade Issues", booktitle = "Banana lectin interactions with the immune system: Implications for future therapeutic applications", pages = "318-307", url = "https://hdl.handle.net/21.15107/rcub_intor_329" }
Gavrović-Jankulović, M., Dimitrijević, R.,& Stojanović, M.. (2011). Banana lectin interactions with the immune system: Implications for future therapeutic applications. in Bananas: Nutrition, Diseases and Trade Issues Nova Science Publishers, Inc.., 307-318. https://hdl.handle.net/21.15107/rcub_intor_329
Gavrović-Jankulović M, Dimitrijević R, Stojanović M. Banana lectin interactions with the immune system: Implications for future therapeutic applications. in Bananas: Nutrition, Diseases and Trade Issues. 2011;:307-318. https://hdl.handle.net/21.15107/rcub_intor_329 .
Gavrović-Jankulović, Marija, Dimitrijević, Rajna, Stojanović, Marijana, "Banana lectin interactions with the immune system: Implications for future therapeutic applications" in Bananas: Nutrition, Diseases and Trade Issues (2011):307-318, https://hdl.handle.net/21.15107/rcub_intor_329 .