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dc.creatorLeposavić, Gordana
dc.creatorPilipović, Ivan
dc.creatorPerišić, Milica
dc.date.accessioned2021-02-18T10:37:15Z
dc.date.available2021-02-18T10:37:15Z
dc.date.issued2011
dc.identifier.issn1021-7401
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/328
dc.description.abstractAgeing is associated with a progressive decline in thymic cytoarchitecture followed by a less efficient T cell development and decreased emigration of naive T cells to the periphery. These thymic changes are linked to increased morbidity and mortality from infectious, malignant and autoimmune diseases in old age. Therefore, it is of paramount importance to understand the thymic homeostatic processes across the life span, as well as to identify factors and elucidate mechanisms driving or contributing to the thymic involution. Catecholamines (CAs) derived from sympathetic nerves and produced locally by thymic cells represent an important component of the thymic microenvironment. In young rats, they provide a subtle tonic suppressive influence on T cell development acting via beta(2)- and alpha(1)-adrenoceptors (ARs) expressed on thymic nonlymphoid cells and thymocytes. In the face of thymic involution, a progressive increase in the thymic noradrenaline level, reflecting a rise in the density of noradrenergic nerve fibers and CA-synthesizing cells, occurs. In addition, the density of beta(2)- and alpha(1)-AR-expressing thymic nonlymphoid cells and the alpha(1)-AR thymocyte surface density also exhibit a pronounced increase with age. The data obtained from studies investigating effects of AR blockade on T cell development indicated that age-related changes in CA-mediated thymic communications, certainly those involving alpha(1)-ARs, may contribute to diminished thymopoietic efficiency in the elderly. Having in mind thymic plasticity in the course of ageing, and broadening possibilities for pharmacological modulation of CA signaling, we here present and discuss the progress in research related to a role of CAs in thymic homeostasis and age-related decay in the thymic naive T cell output. Copyright (C) 2011 S. Karger AG, Baselen
dc.publisherKarger, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceNeuroimmunomodulation
dc.subjectAgeingen
dc.subjectCatecholaminesen
dc.subjectalpha-Adrenoceptorsen
dc.subjectbeta-Adrenoceptorsen
dc.subjectThymopoiesisen
dc.titleAge-Associated Remodeling of Neural and Nonneural Thymic Catecholaminergic Network Affects Thymopoietic Productivityen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage308
dc.citation.issue5
dc.citation.other18(5): 290-308
dc.citation.rankM22
dc.citation.spage290
dc.citation.volume18
dc.identifier.doi10.1159/000329499
dc.identifier.pmid21952681
dc.identifier.rcubconv_271
dc.identifier.scopus2-s2.0-80053343336
dc.identifier.wos000295162000005
dc.type.versionpublishedVersion


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