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dc.creatorMitić, Katarina
dc.creatorStanojević, Stanislava
dc.creatorKuštrimović, Nataša
dc.creatorVujić, Vesna
dc.creatorDimitrijević, Mirjana
dc.date.accessioned2021-02-18T10:37:11Z
dc.date.available2021-02-18T10:37:11Z
dc.date.issued2011
dc.identifier.issn0196-9781
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/327
dc.description.abstractNeuropeptide Y (NPY) has been reported to be a potent anti-inflammatory peptide with ability to directly modulate activity of granulocytes and macrophages. The present study aimed to correlate the effects of NPY in vivo on lipopolysaccharide-induced air-pouch exudates cells and in vitro on peripheral blood leukocytes functions. The role of different Y receptors was examined using NPY-related peptides and antagonists with diverse subtype specificity and selectivity for Y receptors. Y1, Y2 and Y5 receptors were detected on air-pouch exudates cells (flow cytometry) and peripheral blood granulocytes (immunocito-chemistry). NPY in vivo reduced inflammatory cells accumulation into the air pouch, and decreased their adherence and phagocytic capacity via Y2/Y5 and Y1/Y2 receptors, respectively. Quite the opposite, NPY in vitro potentiated adhesiveness and phagocytosis of peripheral blood granulocytes and monocytes by activating Y1 receptor. The differences between in vivo and in vitro effects of NPY on rat inflammatory cells functions are mostly due to dipeptidyl peptidase 4 activity. In addition, suppressive effect of NPY in vivo is highly dependent on the local microenvironment, peptide truncation and specific Y receptors interplay. (C) 2011 Elsevier Inc. All rights reserved.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourcePeptides
dc.subjectGranulocytesen
dc.subjectInflammationen
dc.subjectMonocytesen
dc.subjectNeuropeptide Yen
dc.subjectRaten
dc.subjectY receptor subtypesen
dc.titleNeuropeptide Y modulates functions of inflammatory cells in the rat: Distinct role for Y1, Y2 and Y5 receptorsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1633
dc.citation.issue8
dc.citation.other32(8): 1626-1633
dc.citation.rankM22
dc.citation.spage1626
dc.citation.volume32
dc.identifier.doi10.1016/j.peptides.2011.06.007
dc.identifier.pmid21699939
dc.identifier.rcubconv_270
dc.identifier.scopus2-s2.0-80051544990
dc.identifier.wos000294572800009
dc.type.versionpublishedVersion


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