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dc.creatorŽivković, Irena
dc.creatorStojanović, Marijana
dc.creatorPetrušić, Vladimir
dc.creatorInić-Kanada, Aleksandra
dc.creatorDimitrijević, Ljiljana
dc.date.accessioned2021-02-18T10:36:48Z
dc.date.available2021-02-18T10:36:48Z
dc.date.issued2011
dc.identifier.issn1046-7408
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/321
dc.description.abstractProblem The antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by vascular thrombosis and/or pregnancy complications (lower fecundity and lower litter size), as well as by an increase in anti-beta(2) glycoprotein I (beta(2)GPI)-specific autoantibody titer. We have investigated how the genetic background of the immune system [T helper (Th) prevalence] and the type of animal model of APS influence the induced pathology. Method of Study Antiphospholipid syndrome induced by tetanus toxoid (TTd) hyper-immunization and by intravenous application of monoclonal anti-beta(2)GPI-specific antibody 26 was compared in C57BL/6 (Th1 prone) and BALB/c (Th2 prone) mice. Results Tetanus toxoid hyper-immunization of BALB/c mice led to reduction in fertility, but in C57BL/6 mice a decrease in fecundity occurred. In both cases, pathology was caused by anti-beta(2)GPI antibodies, the production of which was adjuvant and strain dependent. Conclusion We conclude that TTd immunization and i.v. application of monoclonal antibody 26 induced the same reproductive pathology and that the type of pathology is strain dependent.en
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142020/RS//
dc.rightsrestrictedAccess
dc.sourceAmerican Journal of Reproductive Immunology
dc.subjectAntiphospholipid syndromeen
dc.subjectfecundityen
dc.subjectfertilityen
dc.subjectmouse strainen
dc.titleInduction of APS after TTd Hyper-Immunization has a Different Outcome in BALB/c and C57BL/6 Miceen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage502
dc.citation.issue5
dc.citation.other65(5): 492-502
dc.citation.rankM22
dc.citation.spage492
dc.citation.volume65
dc.identifier.doi10.1111/j.1600-0897.2010.00922.x
dc.identifier.pmid21029246
dc.identifier.rcubconv_263
dc.identifier.scopus2-s2.0-79953718040
dc.identifier.wos000289172000005
dc.type.versionpublishedVersion


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