Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE epsilon 3/epsilon 3 genotype (p = .01221) and epsilon 4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.
Keywords:
APOE / genotyping / neuroleptic / schizophrenia / Serbian population
Source:
International Journal of Neuroscience, 2010, 120, 7, 502-506
TY - JOUR
AU - Kecmanović, Miljana
AU - Dobričić, Valerija
AU - Dimitrijević, Rajna
AU - Keckarević, Dušan
AU - Savić-Pavićević, Dušanka
AU - Keckarević-Marković, Milica
AU - Ivković, Maja
AU - Romac, Stanka
PY - 2010
UR - http://intor.torlakinstitut.com/handle/123456789/312
AB - Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE epsilon 3/epsilon 3 genotype (p = .01221) and epsilon 4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.
PB - Taylor & Francis Ltd, Abingdon
T2 - International Journal of Neuroscience
T1 - Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population
EP - 506
IS - 7
SP - 502
VL - 120
DO - 10.3109/00207451003765956
UR - conv_255
ER -
@article{
author = "Kecmanović, Miljana and Dobričić, Valerija and Dimitrijević, Rajna and Keckarević, Dušan and Savić-Pavićević, Dušanka and Keckarević-Marković, Milica and Ivković, Maja and Romac, Stanka",
year = "2010",
abstract = "Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE epsilon 3/epsilon 3 genotype (p = .01221) and epsilon 4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population",
pages = "506-502",
number = "7",
volume = "120",
doi = "10.3109/00207451003765956",
url = "conv_255"
}
Kecmanović, M., Dobričić, V., Dimitrijević, R., Keckarević, D., Savić-Pavićević, D., Keckarević-Marković, M., Ivković, M.,& Romac, S.. (2010). Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 120(7), 502-506.
https://doi.org/10.3109/00207451003765956
conv_255
Kecmanović M, Dobričić V, Dimitrijević R, Keckarević D, Savić-Pavićević D, Keckarević-Marković M, Ivković M, Romac S. Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population. in International Journal of Neuroscience. 2010;120(7):502-506.
doi:10.3109/00207451003765956
conv_255 .
Kecmanović, Miljana, Dobričić, Valerija, Dimitrijević, Rajna, Keckarević, Dušan, Savić-Pavićević, Dušanka, Keckarević-Marković, Milica, Ivković, Maja, Romac, Stanka, "Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population" in International Journal of Neuroscience, 120, no. 7 (2010):502-506,
https://doi.org/10.3109/00207451003765956 .,
conv_255 .
