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dc.creatorPilipović, Ivan
dc.creatorKosec, Duško
dc.creatorRadojević, Katarina
dc.creatorPerišić, Milica
dc.creatorPešić, Vesna
dc.creatorStojić-Vukanić, Zorica
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:35:37Z
dc.date.available2021-02-18T10:35:37Z
dc.date.issued2010
dc.identifier.issn0100-879X
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/303
dc.description.abstractThere is evidence that the major mediators of stress, i.e., catecholamines and glucocorticoids, play an important role in modulating thymopoiesis and consequently immune responses. Furthermore, there are data suggesting that glucocorticoids influence catecholamine action. Therefore, to assess the putative relevance of glucocorticoid-catecholamine interplay in the modulation of thymopoiesis we analyzed thymocyte differentiation/maturation in non-adrenalectomized and andrenalectomized rats subjected to treatment with propranolol (0.4 mg.100 g body weight(-1).day(-1)) for 4 days. The effects of beta-adrenoceptor blockade on thymopoiesis in non-adrenalectomized rats differed not only quantitatively but also qualitatively from those in adrenalectomized rats. In adrenalectomized rats, besides a more efficient thymopoiesis [judged by a more pronounced increase in the relative proportion of the most mature single-positive TCR alpha beta(high) thymocytes as revealed by two-way ANOVA; for CD4(+)CD8(-)F (1,20) = 10.92, P lt 0.01; for CD4(-)CD8(+)F (1,20) = 7.47, P lt 0.05], a skewed thymocyte maturation towards the CD4(-)CD8(+) phenotype, and consequently a diminished CD4(+)CD8(-)/CD4(-)CD8(+) mature TCR alpha beta(high) thymocyte ratio (3.41 +/- 0.21 in non-adrenalectomized rats vs 2.90 +/- 0.31 in adrenalectomized rats, P lt 0.05) were found. Therefore, we assumed that catecholaminergic modulation of thymopoiesis exhibits a substantial degree of glucocorticoid-dependent plasticity. Given that glucocorticoids, apart from catecholamine synthesis, influence adrenoceptor expression, we also hypothesized that the lack of adrenal glucocorticoids affected not only beta-adrenoceptor- but also alpha-adrenoceptor-mediated modulation of thymopoiesis.en
dc.publisherAssoc Bras Divulg Cientifica, Ribeirao Preto
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceBrazilian Journal of Medical and Biological Research
dc.subjectCatecholaminesen
dc.subjectGlucocorticoidsen
dc.subjectbeta-adrenoceptorsen
dc.subjectPropranololen
dc.subjectThymocyte apoptosisen
dc.subjectThymocyte proliferationen
dc.subjectThymocyte differentiationen
dc.titleGlucocorticoids, master modulators of the thymic catecholaminergic system?en
dc.typearticle
dc.rights.licenseBY
dc.citation.epage284
dc.citation.issue3
dc.citation.other43(3): 279-284
dc.citation.rankM22
dc.citation.spage279
dc.citation.volume43
dc.identifier.doi10.1590/S0100-879X2010007500005
dc.identifier.fulltexthttp://intor.torlakinstitut.com/bitstream/id/161/300.pdf
dc.identifier.pmid20401436
dc.identifier.rcubconv_250
dc.identifier.scopus2-s2.0-77950135950
dc.identifier.wos000275596000009
dc.type.versionpublishedVersion


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