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Bordetella pertussis vaccine strains and circulating isolates in Serbia

Authorized Users Only
2010
Authors
Dakić, Gordana
Kallonen, Teemu
Elomaa, Annika
Plješa, Tatjana
Vignjević-Krastavcević, Mirjana
He, Qiushui
Article (Published version)
Metadata
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Abstract
In Serbia, whole cell pertussis vaccine was introduced in 1957. Current composition of the vaccine has been used since 1985 and contains four autochthonous strains of Bordetella pertussis isolated from 1957 to 1984. To monitor changes in bacterial population, 70 isolates collected from 1953 to 2000 were studied together with the vaccine strains. The methods included serotyping of fimbriae (Fim), genotyping of pertactin (prn) and pertussis toxin S1 subunit (ptxA). and pulsed-field gel electrophoresis analysis. Shift from ptxA2 to ptxA1 has been observed in isolates since the late of 1960s. All isolates from 1980 to 1984 harbored ptxA1. Re-appearance of the ptxA2 allele followed an addition of the two strains harboring ptxA1 in the vaccine in 1985. The allele prn1 was predominant among the Serbian isolates, though prn3 and prn11 have been detected since 1981 and 1984. The allele prn2 was found only in two strains isolated in 2000. Serotype Fim2.3 disappeared before 1980 and serotype Fim2... became predominant since then. The Serbian vaccine strains showed differences in ptxA and pm. The results of this present study indicate that the B. pertussis population in Serbia is different from other vaccinated populations and that this difference may be related to the vaccine used. (C) 2009 Elsevier Ltd. All rights reserved.

Keywords:
Bordetella pertussis / Pertussis / Vaccine
Source:
Vaccine, 2010, 28, 5, 1188-1192
Publisher:
  • Elsevier Sci Ltd, Oxford
Funding / projects:
  • Finnish Cultural FoundationFinnish Cultural Foundation

DOI: 10.1016/j.vaccine.2009.11.036

ISSN: 0264-410X

PubMed: 19945417

WoS: 000275122200009

Scopus: 2-s2.0-74249114793
[ Google Scholar ]
7
7
URI
http://intor.torlakinstitut.com/handle/123456789/302
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - JOUR
AU  - Dakić, Gordana
AU  - Kallonen, Teemu
AU  - Elomaa, Annika
AU  - Plješa, Tatjana
AU  - Vignjević-Krastavcević, Mirjana
AU  - He, Qiushui
PY  - 2010
UR  - http://intor.torlakinstitut.com/handle/123456789/302
AB  - In Serbia, whole cell pertussis vaccine was introduced in 1957. Current composition of the vaccine has been used since 1985 and contains four autochthonous strains of Bordetella pertussis isolated from 1957 to 1984. To monitor changes in bacterial population, 70 isolates collected from 1953 to 2000 were studied together with the vaccine strains. The methods included serotyping of fimbriae (Fim), genotyping of pertactin (prn) and pertussis toxin S1 subunit (ptxA). and pulsed-field gel electrophoresis analysis. Shift from ptxA2 to ptxA1 has been observed in isolates since the late of 1960s. All isolates from 1980 to 1984 harbored ptxA1. Re-appearance of the ptxA2 allele followed an addition of the two strains harboring ptxA1 in the vaccine in 1985. The allele prn1 was predominant among the Serbian isolates, though prn3 and prn11 have been detected since 1981 and 1984. The allele prn2 was found only in two strains isolated in 2000. Serotype Fim2.3 disappeared before 1980 and serotype Fim2 became predominant since then. The Serbian vaccine strains showed differences in ptxA and pm. The results of this present study indicate that the B. pertussis population in Serbia is different from other vaccinated populations and that this difference may be related to the vaccine used. (C) 2009 Elsevier Ltd. All rights reserved.
PB  - Elsevier Sci Ltd, Oxford
T2  - Vaccine
T1  - Bordetella pertussis vaccine strains and circulating isolates in Serbia
EP  - 1192
IS  - 5
SP  - 1188
VL  - 28
DO  - 10.1016/j.vaccine.2009.11.036
UR  - conv_249
ER  - 
@article{
author = "Dakić, Gordana and Kallonen, Teemu and Elomaa, Annika and Plješa, Tatjana and Vignjević-Krastavcević, Mirjana and He, Qiushui",
year = "2010",
abstract = "In Serbia, whole cell pertussis vaccine was introduced in 1957. Current composition of the vaccine has been used since 1985 and contains four autochthonous strains of Bordetella pertussis isolated from 1957 to 1984. To monitor changes in bacterial population, 70 isolates collected from 1953 to 2000 were studied together with the vaccine strains. The methods included serotyping of fimbriae (Fim), genotyping of pertactin (prn) and pertussis toxin S1 subunit (ptxA). and pulsed-field gel electrophoresis analysis. Shift from ptxA2 to ptxA1 has been observed in isolates since the late of 1960s. All isolates from 1980 to 1984 harbored ptxA1. Re-appearance of the ptxA2 allele followed an addition of the two strains harboring ptxA1 in the vaccine in 1985. The allele prn1 was predominant among the Serbian isolates, though prn3 and prn11 have been detected since 1981 and 1984. The allele prn2 was found only in two strains isolated in 2000. Serotype Fim2.3 disappeared before 1980 and serotype Fim2 became predominant since then. The Serbian vaccine strains showed differences in ptxA and pm. The results of this present study indicate that the B. pertussis population in Serbia is different from other vaccinated populations and that this difference may be related to the vaccine used. (C) 2009 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Vaccine",
title = "Bordetella pertussis vaccine strains and circulating isolates in Serbia",
pages = "1192-1188",
number = "5",
volume = "28",
doi = "10.1016/j.vaccine.2009.11.036",
url = "conv_249"
}
Dakić, G., Kallonen, T., Elomaa, A., Plješa, T., Vignjević-Krastavcević, M.,& He, Q.. (2010). Bordetella pertussis vaccine strains and circulating isolates in Serbia. in Vaccine
Elsevier Sci Ltd, Oxford., 28(5), 1188-1192.
https://doi.org/10.1016/j.vaccine.2009.11.036
conv_249
Dakić G, Kallonen T, Elomaa A, Plješa T, Vignjević-Krastavcević M, He Q. Bordetella pertussis vaccine strains and circulating isolates in Serbia. in Vaccine. 2010;28(5):1188-1192.
doi:10.1016/j.vaccine.2009.11.036
conv_249 .
Dakić, Gordana, Kallonen, Teemu, Elomaa, Annika, Plješa, Tatjana, Vignjević-Krastavcević, Mirjana, He, Qiushui, "Bordetella pertussis vaccine strains and circulating isolates in Serbia" in Vaccine, 28, no. 5 (2010):1188-1192,
https://doi.org/10.1016/j.vaccine.2009.11.036 .,
conv_249 .

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