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Peripubertal orchidectomy transitorily affects age-associated thymic involution in rats
(Assoc Bras Divulg Cientifica, Sao Paulo, 2007)
The role of gonadal hormones in induction and, particularly, maintenance/ progression of rat thymic involution, which normally starts around puberty, was reassessed by examining the effects of peripubertal orchidectomy on ...
Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain
(Termedia Publishing House Ltd, Poznan, 2019)
Natural killer (NK) cells, influencing dendritic cell (DC)-mediated CD4+ lymphocyte priming in draining lymph nodes (dLNs) and controlling spinal cord (SC) infiltration with encephalitogenic CD4+T lymphocytes, modulate EAE ...
Aging impairs endocytic capacity of splenic dendritic cells from dark agouti rats and alters their response to TLR4 stimulation
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2015)
The study was undertaken considering: i) that relative proportion of distinct subsets of splenic dendritic cells (DCs) is strain-specific and predictive for the susceptibility to autoimmune diseases; ii) age-related changes ...
Age-associated reshaping of the thymocyte differentiation model in male rats / Promene u modelu diferentovanja timocita u mužjaka pacova sa godinama
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2001)
In order to elucidate the features of putative age-related changes in the intrathymic T cell maturation sequence, the thymus weight, thymocyte yield and relative proportions of thymocyte subsets were analyzed at distinct ...
NMDA Receptor Antagonist Memantine Ameliorates Experimental Autoimmune Encephalomyelitis in Aged Rats
(MDPI, 2024)
Aging is closely related to the main aspects of multiple sclerosis (MS). The average age of the MS population is increasing and the number of elderly MS patients is expected to increase. In addition to neurons, ...