Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.
Кључне речи:
E219K / M129V / polymorphism / prion diseases / PRNP / Serbian population
Извор:
International Journal of Neuroscience, 2010, 120, 7, 496-501
TY - JOUR
AU - Dimitrijević, Rajna
AU - Cadez, Ivana
AU - Keckarević-Marković, Milica
AU - Keckarević, Dušan
AU - Kecmanović, Miljana
AU - Dobričić, Valerija
AU - Savić-Pavićević, Dušanka
AU - Brajusković, Goran
AU - Romac, Stanka
PY - 2010
UR - http://intor.torlakinstitut.com/handle/123456789/299
AB - Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.
PB - Taylor & Francis Ltd, Abingdon
T2 - International Journal of Neuroscience
T1 - Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population
EP - 501
IS - 7
SP - 496
VL - 120
DO - 10.3109/00207451003765907
UR - conv_254
ER -
@article{
author = "Dimitrijević, Rajna and Cadez, Ivana and Keckarević-Marković, Milica and Keckarević, Dušan and Kecmanović, Miljana and Dobričić, Valerija and Savić-Pavićević, Dušanka and Brajusković, Goran and Romac, Stanka",
year = "2010",
abstract = "Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population",
pages = "501-496",
number = "7",
volume = "120",
doi = "10.3109/00207451003765907",
url = "conv_254"
}
Dimitrijević, R., Cadez, I., Keckarević-Marković, M., Keckarević, D., Kecmanović, M., Dobričić, V., Savić-Pavićević, D., Brajusković, G.,& Romac, S.. (2010). Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 120(7), 496-501.
https://doi.org/10.3109/00207451003765907
conv_254
Dimitrijević R, Cadez I, Keckarević-Marković M, Keckarević D, Kecmanović M, Dobričić V, Savić-Pavićević D, Brajusković G, Romac S. Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population. in International Journal of Neuroscience. 2010;120(7):496-501.
doi:10.3109/00207451003765907
conv_254 .
Dimitrijević, Rajna, Cadez, Ivana, Keckarević-Marković, Milica, Keckarević, Dušan, Kecmanović, Miljana, Dobričić, Valerija, Savić-Pavićević, Dušanka, Brajusković, Goran, Romac, Stanka, "Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population" in International Journal of Neuroscience, 120, no. 7 (2010):496-501,
https://doi.org/10.3109/00207451003765907 .,
conv_254 .
