Show simple item record

dc.creatorDimitrijević, Mirjana
dc.creatorStanojević, Stanislava
dc.creatorMitić, Katarina
dc.creatorKuštrimović, Nataša
dc.creatorVujić, Vesna
dc.creatorMiletić, Tatjana
dc.creatorKovačević-Jovanović, Vesna
dc.date.accessioned2021-02-18T10:35:17Z
dc.date.available2021-02-18T10:35:17Z
dc.date.issued2010
dc.identifier.issn0167-0115
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/298
dc.description.abstractIt has been acknowledged that aging exerts detrimental effects on cells of the innate immune system and that neuropeptides, including neuropeptide Y (NPY) and NPY-related peptides fine-tune the activity of these cells through a receptor specific mechanism. The present study investigated the age-dependent potential of peptide YY (PYY) to modulate different granulocyte functions. The PYY reduced the carrageenan-elicited granulocyte accumulation into the air-pouch of aged (24 months) rats, and markedly decreased the phagocytosis of zymosan, as well as the H(2)O(2) production, when applied in vivo (20 mu g/air-pouch). The anti-inflammatory effect of PYY was less prominent in adult (8 months) and young (3 months) rats. However, the proportions of granulocytes expressing Y1, Y2 and Y5 receptor subtypes were significantly lower in both aged and young rats when compared to adult rats. Furthermore, the aging was found to be associated with the diminished dipeptidyl peptidase 4 (DP4, an enzyme converting the NPY and PYY to Y2/Y5 receptor selective agonists) activity in plasma. In conclusion, the diverse age-related anti-inflammatory effect of PYY in rats originates from different expression levels of Y1, Y2, and Y5 receptor subtypes in addition to different plasma DP4 activity. (C) 2009 Elsevier B.V. All rights reserved.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceRegulatory Peptides
dc.subjectDipeptidyl peptidase 4 (DP4)en
dc.subjectGranulocytesen
dc.subjectPeptide YY (PYY)en
dc.subjectY receptorsen
dc.subjectRatsen
dc.titleModulation of granulocyte functions by peptide YY in the rat: Age-related differences in Y receptors expression and plasma dipeptidyl peptidase 4 activityen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage109
dc.citation.issue1-3
dc.citation.other159(1-3): 100-109
dc.citation.rankM22
dc.citation.spage100
dc.citation.volume159
dc.identifier.doi10.1016/j.regpep.2009.11.002
dc.identifier.pmid19896984
dc.identifier.rcubconv_245
dc.identifier.scopus2-s2.0-71649090999
dc.identifier.wos000273920500016
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record