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dc.creatorJovanova-Nešić, Katica
dc.creatorKoruga, D.
dc.creatorKojić, D.
dc.creatorKostić, V.
dc.creatorRakić, L.
dc.creatorShoenfeld, Yehuda
dc.date.accessioned2021-02-18T10:34:49Z
dc.date.available2021-02-18T10:34:49Z
dc.date.issued2009
dc.identifier.issn0077-8923
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/291
dc.description.abstractExperimental autoimmune encephalomyelitis (EAE) induced by ventricular injection of antimyelin oligodendrocyte antibodies in DA rats showed severe clinical signs 4 to 5 days after injection. Immunocytochemically, connexin 43 (Cx43) expression increased in the choroid plexus and in the subventricular and subgranular zones of the hippocampus during the development of acute EAE, and decreased after the beginning of the remission phase of the disease. Quantitative computing analysis showed a significantly increased Cx43 expression in the choroid plexus at the peak of the disease. Plaque-pattern expression of the Cx43 in the choroid plexus (CP) of acute EAE correlated with the increased docking and coupling of the Cx43 hemichannels revealed by atomic force microscopy (AFM). The inner diameter of the gap junction (GJ) channels decreased in the CP of acute EAE, measured by AFM. Cell structure conformational changes showed influences the channels' flexibility in acute EAE.en
dc.publisherWiley-Blackwell, Malden
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145057/RS//
dc.rightsrestrictedAccess
dc.sourceContemporary Challenges in Autoimmunity
dc.subjectEAEen
dc.subjectchoroid plexusen
dc.subjectGJen
dc.subjectCx43en
dc.subjectAFM topographyen
dc.titleChoroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAEen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage82
dc.citation.other1173: 75-82
dc.citation.rankaM21
dc.citation.spage75
dc.citation.volume1173
dc.identifier.doi10.1111/j.1749-6632.2009.04658.x
dc.identifier.pmid19758135
dc.identifier.rcubconv_241
dc.identifier.scopus2-s2.0-69949122494
dc.identifier.wos000270762800013
dc.type.versionpublishedVersion


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