Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE
Само за регистроване кориснике
2009
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Experimental autoimmune encephalomyelitis (EAE) induced by ventricular injection of antimyelin oligodendrocyte antibodies in DA rats showed severe clinical signs 4 to 5 days after injection. Immunocytochemically, connexin 43 (Cx43) expression increased in the choroid plexus and in the subventricular and subgranular zones of the hippocampus during the development of acute EAE, and decreased after the beginning of the remission phase of the disease. Quantitative computing analysis showed a significantly increased Cx43 expression in the choroid plexus at the peak of the disease. Plaque-pattern expression of the Cx43 in the choroid plexus (CP) of acute EAE correlated with the increased docking and coupling of the Cx43 hemichannels revealed by atomic force microscopy (AFM). The inner diameter of the gap junction (GJ) channels decreased in the CP of acute EAE, measured by AFM. Cell structure conformational changes showed influences the channels' flexibility in acute EAE.
Кључне речи:
EAE / choroid plexus / GJ / Cx43 / AFM topographyИзвор:
Contemporary Challenges in Autoimmunity, 2009, 1173, 75-82Издавач:
- Wiley-Blackwell, Malden
Финансирање / пројекти:
- Истраживање клиничких и генетичких корелација моторних и немоторних испољавања болести невољних покрета (RS-145057)
DOI: 10.1111/j.1749-6632.2009.04658.x
ISSN: 0077-8923
PubMed: 19758135
WoS: 000270762800013
Scopus: 2-s2.0-69949122494
Институција/група
TorlakTY - JOUR AU - Jovanova-Nešić, Katica AU - Koruga, D. AU - Kojić, D. AU - Kostić, V. AU - Rakić, L. AU - Shoenfeld, Yehuda PY - 2009 UR - http://intor.torlakinstitut.com/handle/123456789/291 AB - Experimental autoimmune encephalomyelitis (EAE) induced by ventricular injection of antimyelin oligodendrocyte antibodies in DA rats showed severe clinical signs 4 to 5 days after injection. Immunocytochemically, connexin 43 (Cx43) expression increased in the choroid plexus and in the subventricular and subgranular zones of the hippocampus during the development of acute EAE, and decreased after the beginning of the remission phase of the disease. Quantitative computing analysis showed a significantly increased Cx43 expression in the choroid plexus at the peak of the disease. Plaque-pattern expression of the Cx43 in the choroid plexus (CP) of acute EAE correlated with the increased docking and coupling of the Cx43 hemichannels revealed by atomic force microscopy (AFM). The inner diameter of the gap junction (GJ) channels decreased in the CP of acute EAE, measured by AFM. Cell structure conformational changes showed influences the channels' flexibility in acute EAE. PB - Wiley-Blackwell, Malden T2 - Contemporary Challenges in Autoimmunity T1 - Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE EP - 82 SP - 75 VL - 1173 DO - 10.1111/j.1749-6632.2009.04658.x ER -
@article{ author = "Jovanova-Nešić, Katica and Koruga, D. and Kojić, D. and Kostić, V. and Rakić, L. and Shoenfeld, Yehuda", year = "2009", abstract = "Experimental autoimmune encephalomyelitis (EAE) induced by ventricular injection of antimyelin oligodendrocyte antibodies in DA rats showed severe clinical signs 4 to 5 days after injection. Immunocytochemically, connexin 43 (Cx43) expression increased in the choroid plexus and in the subventricular and subgranular zones of the hippocampus during the development of acute EAE, and decreased after the beginning of the remission phase of the disease. Quantitative computing analysis showed a significantly increased Cx43 expression in the choroid plexus at the peak of the disease. Plaque-pattern expression of the Cx43 in the choroid plexus (CP) of acute EAE correlated with the increased docking and coupling of the Cx43 hemichannels revealed by atomic force microscopy (AFM). The inner diameter of the gap junction (GJ) channels decreased in the CP of acute EAE, measured by AFM. Cell structure conformational changes showed influences the channels' flexibility in acute EAE.", publisher = "Wiley-Blackwell, Malden", journal = "Contemporary Challenges in Autoimmunity", title = "Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE", pages = "82-75", volume = "1173", doi = "10.1111/j.1749-6632.2009.04658.x" }
Jovanova-Nešić, K., Koruga, D., Kojić, D., Kostić, V., Rakić, L.,& Shoenfeld, Y.. (2009). Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE. in Contemporary Challenges in Autoimmunity Wiley-Blackwell, Malden., 1173, 75-82. https://doi.org/10.1111/j.1749-6632.2009.04658.x
Jovanova-Nešić K, Koruga D, Kojić D, Kostić V, Rakić L, Shoenfeld Y. Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE. in Contemporary Challenges in Autoimmunity. 2009;1173:75-82. doi:10.1111/j.1749-6632.2009.04658.x .
Jovanova-Nešić, Katica, Koruga, D., Kojić, D., Kostić, V., Rakić, L., Shoenfeld, Yehuda, "Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE" in Contemporary Challenges in Autoimmunity, 1173 (2009):75-82, https://doi.org/10.1111/j.1749-6632.2009.04658.x . .