Show simple item record

dc.creatorLeposavić, Gordana
dc.creatorPerišić, Milica
dc.creatorKosec, Duško
dc.creatorArsenović-Ranin, Nevena
dc.creatorRadojević, Katarina
dc.creatorStojić-Vukanić, Zorica
dc.creatorPilipović, Ivan
dc.date.accessioned2021-02-18T10:34:42Z
dc.date.available2021-02-18T10:34:42Z
dc.date.issued2009
dc.identifier.issn0889-1591
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/289
dc.description.abstractExposure of female rodents to testosterone in the critical neonatal period produces defeminization/masculinization of the hypothalamo-pituitary-gonadal (HPG) axis, i.e. neonatal androgenization and postpones axis maturation. To address the hypothesis that HPG axis signaling is involved in the programming of thymic maturation/involution and sexual differentiation we studied the impact of neonatal androgenization on thymic cellularity, development of effector and regulatory T cells, and phenotypic characteristics of peripheral blood T lymphocytes in adult rats. A single injection of testosterome on postnatal day 2 postponed thymic maturation/involution as revealed by organ hypercellularity, increased cellularity of the most mature (CD4+CD8- and CD4-CD8+) TCR alpha beta(high) thymocyte and both recent thymic emigrant (RTE) subsets and caused phenotypic efeminization/masculinization of thymic (decreased CD4+CD8-TCR alpha beta(high)/CD4-CD8+TCR alpha beta(high) cell ratio) and peripheral blood T-cell compartments (decreased CD4+RTE/CD8+RTE and CD4+/CD8+ cell ratio). In addition, neonatal androgenization increased the relative and absolute numbers of both CD4+CD25+Foxp3+ and natural killer (NK) regulatory T cells in peripheral blood. These findings, in conjunction with thymocyte overexpression of Thy-1 that is assumed to reduce negative selection affecting self-reactive cell generation, suggest a new relationship between self-reactive and regulatory T cells. In conclusion, our study provides additional evidence for a role of HPG signals (i.e. sex steroids and gonadotropins) in programming the kinetics of thymic maturation/involution and in establishing immunological sexual dimorphism. (C) 2008 Elsevier Inc. All rights reserved.en
dc.publisherAcademic Press Inc Elsevier Science, San Diego
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceBrain Behavior and Immunity
dc.subjectNeonatal androgenizationen
dc.subjectT-cell differentiationen
dc.subjectPeripheral blood T lymphocytesen
dc.subjectRecent thymic emigrantsen
dc.titleNeonatal testosterone imprinting affects thymus development and leads to phenotypic rejuvenation and masculinization of the peripheral blood T-cell compartment in adult female ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage304
dc.citation.issue2
dc.citation.other23(2): 294-304
dc.citation.rankM21
dc.citation.spage294
dc.citation.volume23
dc.identifier.doi10.1016/j.bbi.2008.11.002
dc.identifier.pmid19028560
dc.identifier.rcubconv_228
dc.identifier.scopus2-s2.0-58749102933
dc.identifier.wos000263134100019
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record