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dc.creatorStojanović, Marijana
dc.creatorŽivković, Irena
dc.creatorInić-Kanada, Aleksandra
dc.creatorPetrušić, Vladimir
dc.creatorMićić, Mileva
dc.creatorDimitrijević, Ljiljana
dc.date.accessioned2021-02-18T10:34:22Z
dc.date.available2021-02-18T10:34:22Z
dc.date.issued2009
dc.identifier.issn0385-5600
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/284
dc.description.abstractResults are presented concerning our attempts to create a suitable model system for studying the connection between microbial antigen (micAg), autoimmunity and autoimmune disease on the basis of hyper-immunization and application of micAg in different contexts. Our research was focused on tetanus toxoid (TTd) as a model micAg. Non-pretreated and complete Freund's adjuvant pretreated BALB/c mice were immunized with high doses of TTd mixed with glycerol or aluminum hydroxide as adjuvants. The main aims of the experiments were to evaluate the properties of induced humoral immune responses, evaluate the pathological potential of induced immune responses and determine possible correlations between the properties of a humoral immune response and its pathological potential. The production of TTd-specific and self-reactive beta(2)-glycoprotein I (beta(2)-GP I)-specific antibodies (Abs) was detected in all groups but with specific, context-related properties. Analysis of pregnancy-related pathology (anti-beta(2)-GP I Abs-associated) showed differences in the pathological potential of the induced immune response. It was demonstrated that severity of pathology is positively correlated to the abundance of IgG that recognizes beta(2)-GP I adsorbed onto phosphatidylserine, and to IgG affinity. Furthermore, it was demonstrated that molecular mimicry, which results in generation of anti-beta(2)-GP I Abs upon TTd immunization, is necessary but not sufficient for the development of pregnancy-related pathology.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142020/RS//
dc.rightsopenAccess
dc.sourceMicrobiology and Immunology
dc.subjectadjuvanten
dc.subjectanti-beta(2)-glycoprotein I antibodyen
dc.subjecttetanus toxoiden
dc.titleThe context of tetanus toxoid application influences the outcome of antigen-specific and self-directed humoral immune responseen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage100
dc.citation.issue2
dc.citation.other53(2): 89-100
dc.citation.rankM23
dc.citation.spage89
dc.citation.volume53
dc.identifier.doi10.1111/j.1348-0421.2008.00094.x
dc.identifier.fulltexthttp://intor.torlakinstitut.com/bitstream/id/140/281.pdf
dc.identifier.pmid19291092
dc.identifier.rcubconv_230
dc.identifier.scopus2-s2.0-64049108541
dc.identifier.wos000263853200005
dc.type.versionpublishedVersion


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