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dc.creatorDimitrijević, Mirjana
dc.creatorPilipović, Ivan
dc.creatorStanojević, Stanislava
dc.creatorMitić, Katarina
dc.creatorRadojević, Katarina
dc.creatorPešić, Vesna
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:33:36Z
dc.date.available2021-02-18T10:33:36Z
dc.date.issued2009
dc.identifier.issn0165-5728
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/273
dc.description.abstractUsing both immunocytochemical and flow cytometric analyses of rat peritoneal exudate cells constitutive expression of tyrosine hydroxylase and both beta(2)- and alpha(1)-adrenoceptors on macrophages was revealed. Furthermore, according to the characteristic assemblage of tyrosine hydroxylase and adrenoceptor subtype expression different macrophage subsets were identified. In vitro treatment of macrophages with the nonselective alpha,beta-adrenoceptor agonist arterenol and/or the beta-adrenoceptor antagonist propranolol indicated that beta-adrenoceptors potentiated nitric oxide (NO) production and suggested alpha-adrenoceptor-mediated suppression of hydrogen peroxide (H2O2) production. An increase in H2O2 production in the presence of the alpha(1)-adrenoceptor antagonist ebrantil provided support for this. Chronic propranolol treatment in vivo led to increased NO and H2O2 production by peritoneal macrophages. Furthermore, this treatment resulted in opposing effects on the expression Of beta(2)- and alpha(1)-adrenoceptors on peritoneal macrophages (a stimulatory effect on beta(2)-adrenoceptors and a suppressive effect on alpha(1)-adrenoceptors). In conclusion, a subset of resident peritoneal macrophages synthesizes catecholamines, which may exert differential effects on H2O2 and NO production via distinct adrenoceptors. Finally, chronic propranolol treatment affected adrenoceptor expression on peritoneal macrophages and altered their capacity to generate NO and H2O2. (C) 2009 Elsevier B.V. All rights reserved.en
dc.publisherElsevier, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Neuroimmunology
dc.subjectalpha-adrenoceptoren
dc.subjectbeta-adrenoceptoren
dc.subjectCatecholaminesen
dc.subjectMacrophagesen
dc.subjectRaten
dc.titleChronic propranolol treatment affects expression of adrenoceptors on peritoneal macrophages and their ability to produce hydrogen peroxide and nitric oxideen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage65
dc.citation.issue1-2
dc.citation.other211(1-2): 56-65
dc.citation.rankM22
dc.citation.spage56
dc.citation.volume211
dc.identifier.doi10.1016/j.jneuroim.2009.03.014
dc.identifier.pmid19398131
dc.identifier.rcubconv_238
dc.identifier.scopus2-s2.0-67349256113
dc.identifier.wos000268035000006
dc.type.versionpublishedVersion


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