Show simple item record

dc.creatorLeposavić, Gordana
dc.creatorPerišić, Milica
dc.date.accessioned2021-02-18T10:33:16Z
dc.date.available2021-02-18T10:33:16Z
dc.date.issued2008
dc.identifier.issn1021-7401
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/268
dc.description.abstractThe present review summarizes recent data on age-related thymic changes termed thymic involution, and highlights the putative role of perturbances in extrathymical and, possibly, intrathymical production of gonadal steroids and catecholamines in this process. Thymic involution has been envisaged as an extremely complex process involving multifactorial mechanisms along the bone marrow-thymic axis that accounts for the major manifestations of immunosenescence. These mechanisms include basic cell aging processes (for example, cell replication and programmed cell death) and processes unique to the immune system (such as generation of the T cell receptor repertoire and control of potentially autoreactive cells). Given that the onset of age-associated thymic involution coincides with the rise in gonadal steroid levels at puberty, a causal link between these events has been suggested. It has been shown that: (1) peripubertal gonadectomy causes substantial decrease in the level of noradrenaline in adult male and female thymus and (2) catecholamines, acting via alpha- and beta-adrenoceptor, produce suppressive effects on the thymic cellularity and production of both effector and regulatory T cells. Furthermore, the possibility that gonadal steroids contribute to thymic involution is discussed in this paper. In light of recent data indicating that effects of gonadal hormone deprivation on the thymic cellularity and function are long lasting but transitory, a putative role for the intrathymic sex steroid/catecholamine production in assuring the organ involution, under conditions of their limited supply by extrathymic sources, is also considered. Copyright (C) 2008 S. Karger AG, Baselen
dc.publisherKarger, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceNeuroimmunomodulation
dc.subjectThymusen
dc.subjectInvolutionen
dc.subjectThymopoiesisen
dc.subjectSex steroidsen
dc.subjectCatecholaminesen
dc.titleAge-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholaminesen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage322
dc.citation.issue4-6
dc.citation.other15(4-6): 290-322
dc.citation.rankM23
dc.citation.spage290
dc.citation.volume15
dc.identifier.doi10.1159/000156473
dc.identifier.pmid19047807
dc.identifier.rcubconv_222
dc.identifier.scopus2-s2.0-57149085680
dc.identifier.wos000261564000010
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record