Show simple item record

dc.creatorStanojević, Stanislava
dc.creatorKuštrimović, Nataša
dc.creatorMitić, Katarina
dc.creatorMiletić, Tatjana
dc.creatorVujić, Vesna
dc.creatorKovačević-Jovanović, Vesna
dc.creatorDimitrijević, Mirjana
dc.date.accessioned2021-02-18T10:32:43Z
dc.date.available2021-02-18T10:32:43Z
dc.date.issued2008
dc.identifier.issn1021-7401
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/260
dc.description.abstractBackground: Given that stressful experiences can change the reaction to a subsequent exposure to stress, we tested the in vitro effects of the stress mediator corticosterone and the opioid peptide beta-endorphin on the function of macrophages isolated from control rats and from rats exposed to electric tail shock stress (ES) or a stress-witnessing procedure (SW) 24 h earlier. Methods: Peritoneal macrophages isolated from control and stressed rats of the Dark Agouti (DA) strain were treated in vitro with corticosterone or beta-endorphin and tested for adherence, phagocytosis and hydrogen peroxide release. Results: ES diminished adherence and SW decreased phagocytosis. The suppressive effect of corticosterone on phagocytosis was absent in rats exposed to ES and SW, while the suppressive effect of beta-endorphin on adherence was not observed in rats exposed to SW. ES and SW did not affect H2O2 release, neither directly nor indirectly by changing macrophage response to corticosterone and beta-endorphin in this test. Conclusions: In DA rats early macrophage activation steps, i.e. adherence and phagocytosis, were more sensitive to stress than their effector function, corresponding to H2O2 production. We suggest that neuroendocrine mediators of stress that converge on macrophages might have changed specific macrophage receptors or postreceptor events and alter their response to artificial stressors, represented by corticosterone and beta-endorphin in vitro. Copyright (C) 2008 S. Karger AG, Basel.en
dc.publisherKarger, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceNeuroimmunomodulation
dc.subjectcorticosteroneen
dc.subjectDark Agouti ratsen
dc.subjectelectric tail shock stressen
dc.subjectbeta-endorphinen
dc.subjectperitoneal macrophagesen
dc.subjectstress-witnessing procedureen
dc.titleThe effects of corticosterone and beta-endorphin on adherence, phagocytosis and hydrogen peroxide production of macrophages isolated from Dark Agouti rats exposed to acute stressen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage116
dc.citation.issue2
dc.citation.other15(2): 108-116
dc.citation.rankM23
dc.citation.spage108
dc.citation.volume15
dc.identifier.doi10.1159/000148193
dc.identifier.pmid18679049
dc.identifier.rcubconv_220
dc.identifier.scopus2-s2.0-48449096083
dc.identifier.wos000258878900003
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record