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Catecholamines as immunomodulators: A role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development
dc.creator | Leposavić, Gordana | |
dc.creator | Pilipović, Ivan | |
dc.creator | Radojević, Katarina | |
dc.creator | Pešić, Vesna | |
dc.creator | Perišić, Milica | |
dc.creator | Kosec, Duško | |
dc.date.accessioned | 2021-02-18T10:31:30Z | |
dc.date.available | 2021-02-18T10:31:30Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 1566-0702 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/244 | |
dc.description.abstract | In its simplest form, effective T cell-mediated immunity emanates from the expansion of specific T cells activated tit response to antigen. In establishing and maintaining the peripheral T-cell pool, the thymus plays a critical role. It does so by providing a microenvironment within which T cell precursors proliferate, differentiate and Undergo selection processes to create a fully functional population of major histocompatibility complex restricted, self-tolerant T cells. The control of the thymic function involves intrathymic, as well as sympathetic nervous and endocrine system signalling. In addition to postganglionic noradrenergic fibres, both thymic lymphoid and non-lymphoid cells, including epithelial cells and macrophages. have been demo nstrated to express tyrosine hydroxylase (TH), and Suggested to form a local non-neural catecholaminergic cell network. A higher level of noradrenaline has been found in male than in female rat thymi. and a role of,gonadal hormones ill providing this dimorphism has been demonstrated. In addition, thymic lymphoid and non-lymphoid cells, including those expressing TH, have been found to bear beta- and alpha(1)-adrenoceptors (ARs) and a role of gonadal hormones in regulation of, at least. beta-AR density and signalling has been Suggested. These findings have also entailed conclusion that catecholamiens (CAs) influence T-cell development, not only via neurocrine/endocrine, but also via autocrine/paracrine action. Generally, CAs have been shown to exert an inhibitory influence on thymopoiesis. Role of alpha(1)- and beta-R-mediated mechanisms in maintaining thymic homeostasis and in fine tuning of both conventional and regulatory T-cell development is discussed in the Manuscript. (C) 2008 Elsevier B.V. All rights reserved. | en |
dc.publisher | Elsevier Science Bv, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS// | |
dc.rights | restrictedAccess | |
dc.source | Autonomic Neuroscience-Basic & Clinical | |
dc.subject | Tyrosine hydroxylase immunoreactivity | en |
dc.subject | Sympathetic innervation | en |
dc.subject | beta-adrenoceptors | en |
dc.subject | alpha 1-adrenoceptors | en |
dc.subject | Thymopoiesis | en |
dc.title | Catecholamines as immunomodulators: A role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 12 | |
dc.citation.issue | 1-2 | |
dc.citation.other | 144(1-2): 1-12 | |
dc.citation.rank | M23 | |
dc.citation.spage | 1 | |
dc.citation.volume | 144 | |
dc.identifier.doi | 10.1016/j.autneu.2008.09.003 | |
dc.identifier.pmid | 18976969 | |
dc.identifier.scopus | 2-s2.0-56349095878 | |
dc.identifier.wos | 000261857300001 | |
dc.type.version | publishedVersion |