Приказ основних података о документу

dc.creatorLeposavić, Gordana
dc.creatorPilipović, Ivan
dc.creatorRadojević, Katarina
dc.creatorPešić, Vesna
dc.creatorPerišić, Milica
dc.creatorKosec, Duško
dc.date.accessioned2021-02-18T10:31:30Z
dc.date.available2021-02-18T10:31:30Z
dc.date.issued2008
dc.identifier.issn1566-0702
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/244
dc.description.abstractIn its simplest form, effective T cell-mediated immunity emanates from the expansion of specific T cells activated tit response to antigen. In establishing and maintaining the peripheral T-cell pool, the thymus plays a critical role. It does so by providing a microenvironment within which T cell precursors proliferate, differentiate and Undergo selection processes to create a fully functional population of major histocompatibility complex restricted, self-tolerant T cells. The control of the thymic function involves intrathymic, as well as sympathetic nervous and endocrine system signalling. In addition to postganglionic noradrenergic fibres, both thymic lymphoid and non-lymphoid cells, including epithelial cells and macrophages. have been demo nstrated to express tyrosine hydroxylase (TH), and Suggested to form a local non-neural catecholaminergic cell network. A higher level of noradrenaline has been found in male than in female rat thymi. and a role of,gonadal hormones ill providing this dimorphism has been demonstrated. In addition, thymic lymphoid and non-lymphoid cells, including those expressing TH, have been found to bear beta- and alpha(1)-adrenoceptors (ARs) and a role of gonadal hormones in regulation of, at least. beta-AR density and signalling has been Suggested. These findings have also entailed conclusion that catecholamiens (CAs) influence T-cell development, not only via neurocrine/endocrine, but also via autocrine/paracrine action. Generally, CAs have been shown to exert an inhibitory influence on thymopoiesis. Role of alpha(1)- and beta-R-mediated mechanisms in maintaining thymic homeostasis and in fine tuning of both conventional and regulatory T-cell development is discussed in the Manuscript. (C) 2008 Elsevier B.V. All rights reserved.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceAutonomic Neuroscience-Basic & Clinical
dc.subjectTyrosine hydroxylase immunoreactivityen
dc.subjectSympathetic innervationen
dc.subjectbeta-adrenoceptorsen
dc.subjectalpha 1-adrenoceptorsen
dc.subjectThymopoiesisen
dc.titleCatecholamines as immunomodulators: A role for adrenoceptor-mediated mechanisms in fine tuning of T-cell developmenten
dc.typearticle
dc.rights.licenseARR
dc.citation.epage12
dc.citation.issue1-2
dc.citation.other144(1-2): 1-12
dc.citation.rankM23
dc.citation.spage1
dc.citation.volume144
dc.identifier.doi10.1016/j.autneu.2008.09.003
dc.identifier.pmid18976969
dc.identifier.scopus2-s2.0-56349095878
dc.identifier.wos000261857300001
dc.type.versionpublishedVersion


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Приказ основних података о документу