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dc.creatorPešić, Vesna
dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorRadojević, Katarina
dc.creatorKosec, Duško
dc.creatorPilipović, Ivan
dc.creatorPerišić, Milica
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:31:08Z
dc.date.available2021-02-18T10:31:08Z
dc.date.issued2007
dc.identifier.issn1567-5769
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/239
dc.description.abstractAge-related increase in the density of thymic noradrenergic fibres and noradrenaline (NA) concentration is proposed to be associated with thymic involution and altered thymopoiesis. To test this hypothesis thymocyte differentiation/maturation and thymic structure were studied in 18-month-old male Wistar rats subjected to 14-day-long propranolol (P) blockade of ss-adrenoceptors (ss-ARs). The treatment primarily resulted in changes in the T-cell receptor (TCR)-dependent stages of thymopoiesis, which led to an increase in both the relative and absolute numbers of the most mature single positive (SP) CD4(+)CD8(-) (including cells with the CD4(+)CD25(+) regulatory phenotype) and CD4(-)CD8(+) TCR alpha ss(high) thymocytes. Accordingly, in the thymi of these rats an increase in both numerical density and absolute number of medullary thymocytes encompassing mainly the most mature SP cells was found. These findings, together with an increase in the thymocyte surface expression of the regulatory molecule Thy-1 (CD90) (implicated in negative regulation of TCR alpha beta-dependent thymocyte selection thresholds) in the same rats, may suggest increased positive/reduced negative thymocyte selection. Collectively, the results indicate that a decline in thymic efficiency in generating both conventional and regulatory T cells, and consequently in immune function, in aged rats may be, at least partly, attenuated by long-term blockade of beta-ARs with P. (c) 2007 Elsevier B.V. All rights reserved.en
dc.publisherElsevier, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Immunopharmacology
dc.subjectbeta-adrenoceptor blockadeen
dc.subjectageingen
dc.subjectthymocyte differentiation/maturationen
dc.subjectCD90 expressionen
dc.titleLong-term beta-adrenergic receptor blockade increases levels of the most mature thymocyte subsets in aged ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage686
dc.citation.issue5
dc.citation.other7(5): 674-686
dc.citation.rankM22
dc.citation.spage674
dc.citation.volume7
dc.identifier.doi10.1016/j.intimp.2007.01.017
dc.identifier.pmid17386415
dc.identifier.rcubconv_194
dc.identifier.scopus2-s2.0-33947363946
dc.identifier.wos000245971800013
dc.type.versionpublishedVersion


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