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dc.creatorMitić, Katarina
dc.creatorStanojević, Stanislava
dc.creatorKuštrimović, Nataša
dc.creatorDimitrijević, Mirjana
dc.date.accessioned2021-02-18T10:30:47Z
dc.date.available2021-02-18T10:30:47Z
dc.date.issued2007
dc.identifier.issn1023-3830
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/234
dc.description.abstractThe objective of the present study was to investigate the relevance of peripheral macrophage activity for the susceptibility to the induction of experimental allergic encephalomyelitis (EAE). Rats of EAE-susceptible Dark Agouti and EAEresistant Albino Oxford strain were immunized with guinea pig spinal cord homogenate (DA(GPSC) and AO(GPSC)), while non-immunized rats served as controls (DA(NIM), AO(NIM))- On day 15 after immunization rats were sacrificed and their peritoneal macrophages tested for adherence capacity, zymosan phagocytosis and respiratory burst. Macrophages from AO(NIM) rats exhibited lower adherence capacity and higher phagocytosis and H2O2 production when compared to macrophages from DA(NIM) rats. Immunization with GPSC decreased adherence and phagocytosis and increased H2O2 production in macrophages from AO rats, but did not influence these activities in macrophages from DA rats. The results from the present study suggest that inflammatory activities of macrophages from AO rats could be considered as regulatory mechanisms connected with the resistance to EAE induction.en
dc.publisherSpringer Basel Ag, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceInflammation Research
dc.titleStrain differences in peritoneal macrophage activity and susceptibility to experimental allergic encephalomyelitis induction in ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epageS498
dc.citation.other56: S495-S498
dc.citation.rankM23
dc.citation.spageS495
dc.citation.volume56
dc.identifier.doi10.1007/BF03353888
dc.identifier.rcubconv_197
dc.identifier.scopus2-s2.0-50249159749
dc.identifier.wos000247517900339
dc.type.versionpublishedVersion


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