It is well known that somatostatin modulates thymic functions, such as binding to receptors. In order to elucidate the influence of somatostatin on the thymus architecture and the T cells maturation, young adult male rats were treated with somatostatin-28. The results showed that somatostatin-28 decreased thymus weight and cellularity, probably due to alterations in the thymic morphometric parameters. Our results also demonstrated that SRIH treatment reduces number of cells with undetectable alpha beta TCR and cells with low expression of alpha beta TCR, while the number of TCR alpha beta(hi) cells remains approximately the same as the values obtained from the control rats. Besides, in the least mature thymocytes (DNTCR TCR alpha beta(-)) and among the most mature the SPCD4 TCR alpha beta(hi) subset remained unaltered, while SPCD8 TCR alpha beta(hi) decreased. At last, it should be noted that SRIH treatment increases DN thymocytes subsets expressing TCR alpha beta(low/hi) (TCR alpha be...ta(+)). These results suggest that somatostatin-28 induces reshaping of T cells maturation and, at least partly, contributes to thymic weight loss, through the modulation of the complex neuroendocrine-immune network. (C) 2007 Elsevier B.V. All rights reserved.
Keywords:
rodent / thymus / T cells development / somatostatin
TY - JOUR
AU - Petrović-Đergović, Danica M.
AU - Rakin, Ana
AU - Kuštrimović, Nataša
AU - Ristovski, Jasmina S.
AU - Dimitrijević, Ljiljana
AU - Mićić, Mileva
PY - 2007
UR - http://intor.torlakinstitut.com/handle/123456789/233
AB - It is well known that somatostatin modulates thymic functions, such as binding to receptors. In order to elucidate the influence of somatostatin on the thymus architecture and the T cells maturation, young adult male rats were treated with somatostatin-28. The results showed that somatostatin-28 decreased thymus weight and cellularity, probably due to alterations in the thymic morphometric parameters. Our results also demonstrated that SRIH treatment reduces number of cells with undetectable alpha beta TCR and cells with low expression of alpha beta TCR, while the number of TCR alpha beta(hi) cells remains approximately the same as the values obtained from the control rats. Besides, in the least mature thymocytes (DNTCR TCR alpha beta(-)) and among the most mature the SPCD4 TCR alpha beta(hi) subset remained unaltered, while SPCD8 TCR alpha beta(hi) decreased. At last, it should be noted that SRIH treatment increases DN thymocytes subsets expressing TCR alpha beta(low/hi) (TCR alpha beta(+)). These results suggest that somatostatin-28 induces reshaping of T cells maturation and, at least partly, contributes to thymic weight loss, through the modulation of the complex neuroendocrine-immune network. (C) 2007 Elsevier B.V. All rights reserved.
PB - Elsevier Science Bv, Amsterdam
T2 - Regulatory Peptides
T1 - Somatostatin modulates T cells development in adult rat thymus
EP - 110
IS - 3
SP - 101
VL - 142
DO - 10.1016/j.regpep.2007.02.003
ER -
@article{
author = "Petrović-Đergović, Danica M. and Rakin, Ana and Kuštrimović, Nataša and Ristovski, Jasmina S. and Dimitrijević, Ljiljana and Mićić, Mileva",
year = "2007",
url = "http://intor.torlakinstitut.com/handle/123456789/233",
abstract = "It is well known that somatostatin modulates thymic functions, such as binding to receptors. In order to elucidate the influence of somatostatin on the thymus architecture and the T cells maturation, young adult male rats were treated with somatostatin-28. The results showed that somatostatin-28 decreased thymus weight and cellularity, probably due to alterations in the thymic morphometric parameters. Our results also demonstrated that SRIH treatment reduces number of cells with undetectable alpha beta TCR and cells with low expression of alpha beta TCR, while the number of TCR alpha beta(hi) cells remains approximately the same as the values obtained from the control rats. Besides, in the least mature thymocytes (DNTCR TCR alpha beta(-)) and among the most mature the SPCD4 TCR alpha beta(hi) subset remained unaltered, while SPCD8 TCR alpha beta(hi) decreased. At last, it should be noted that SRIH treatment increases DN thymocytes subsets expressing TCR alpha beta(low/hi) (TCR alpha beta(+)). These results suggest that somatostatin-28 induces reshaping of T cells maturation and, at least partly, contributes to thymic weight loss, through the modulation of the complex neuroendocrine-immune network. (C) 2007 Elsevier B.V. All rights reserved.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Regulatory Peptides",
title = "Somatostatin modulates T cells development in adult rat thymus",
pages = "110-101",
number = "3",
volume = "142",
doi = "10.1016/j.regpep.2007.02.003"
}
Petrović-Đergović, D. M., Rakin, A., Kuštrimović, N., Ristovski, J. S., Dimitrijević, L.,& Mićić, M. (2007). Somatostatin modulates T cells development in adult rat thymus.
Regulatory Peptides
Elsevier Science Bv, Amsterdam., 142(3), 101-110.
https://doi.org/10.1016/j.regpep.2007.02.003
Petrović-Đergović DM, Rakin A, Kuštrimović N, Ristovski JS, Dimitrijević L, Mićić M. Somatostatin modulates T cells development in adult rat thymus. Regulatory Peptides. 2007;142(3):101-110
Petrović-Đergović Danica M., Rakin Ana, Kuštrimović Nataša, Ristovski Jasmina S., Dimitrijević Ljiljana, Mićić Mileva, "Somatostatin modulates T cells development in adult rat thymus" Regulatory Peptides, 142, no. 3 (2007):101-110,
https://doi.org/10.1016/j.regpep.2007.02.003 .
