We studied the effects of neuropeptide Y (NPY) and NPY-related receptor specific peptides on functions of carrageenan-elicited granulocytes in vitro and ability of NPY to modulate carrageenan-induced air pouch inflammation in rats in vivo. Anti-inflammatory effect of NPY comprises reduced granulocyte accumulation into the air pouch, to some extent attenuation of phagocytosis, attained via Y1 receptor, and considerable decrease in peroxide production, albeit mediated via Y2 and Y5 receptors activation. Conversely, NPY increases nitric oxide production and this potentiation is mediated via Y1 receptor. It is concluded that NPY Y1 and Y2/Y5 receptors' interaction participates in NPY-induced modulation of granulocyte functions related to inflammation. (c) 2006 Elsevier Inc. All rights reserved.
Кључне речи:
neuropeptide y (NPY) / NPY receptors / inflammation / granulocytes rat
TY - JOUR
AU - Dimitrijević, Mirjana
AU - Stanojević, Stanislava
AU - Micić, Stana
AU - Vujić, Vesna
AU - Kovačević-Jovanović, Vesna
AU - Mitić, Katarina
AU - von Hoersten, Stephan
AU - Kosec, Duško
PY - 2006
UR - http://intor.torlakinstitut.com/handle/123456789/218
AB - We studied the effects of neuropeptide Y (NPY) and NPY-related receptor specific peptides on functions of carrageenan-elicited granulocytes in vitro and ability of NPY to modulate carrageenan-induced air pouch inflammation in rats in vivo. Anti-inflammatory effect of NPY comprises reduced granulocyte accumulation into the air pouch, to some extent attenuation of phagocytosis, attained via Y1 receptor, and considerable decrease in peroxide production, albeit mediated via Y2 and Y5 receptors activation. Conversely, NPY increases nitric oxide production and this potentiation is mediated via Y1 receptor. It is concluded that NPY Y1 and Y2/Y5 receptors' interaction participates in NPY-induced modulation of granulocyte functions related to inflammation. (c) 2006 Elsevier Inc. All rights reserved.
PB - Elsevier Science Inc, New York
T2 - Peptides
T1 - Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch
EP - 3215
IS - 12
SP - 3208
VL - 27
DO - 10.1016/j.peptides.2006.08.018
UR - conv_109
ER -
@article{
author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Micić, Stana and Vujić, Vesna and Kovačević-Jovanović, Vesna and Mitić, Katarina and von Hoersten, Stephan and Kosec, Duško",
year = "2006",
abstract = "We studied the effects of neuropeptide Y (NPY) and NPY-related receptor specific peptides on functions of carrageenan-elicited granulocytes in vitro and ability of NPY to modulate carrageenan-induced air pouch inflammation in rats in vivo. Anti-inflammatory effect of NPY comprises reduced granulocyte accumulation into the air pouch, to some extent attenuation of phagocytosis, attained via Y1 receptor, and considerable decrease in peroxide production, albeit mediated via Y2 and Y5 receptors activation. Conversely, NPY increases nitric oxide production and this potentiation is mediated via Y1 receptor. It is concluded that NPY Y1 and Y2/Y5 receptors' interaction participates in NPY-induced modulation of granulocyte functions related to inflammation. (c) 2006 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Peptides",
title = "Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch",
pages = "3215-3208",
number = "12",
volume = "27",
doi = "10.1016/j.peptides.2006.08.018",
url = "conv_109"
}
Dimitrijević, M., Stanojević, S., Micić, S., Vujić, V., Kovačević-Jovanović, V., Mitić, K., von Hoersten, S.,& Kosec, D.. (2006). Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch. in Peptides
Elsevier Science Inc, New York., 27(12), 3208-3215.
https://doi.org/10.1016/j.peptides.2006.08.018
conv_109
Dimitrijević M, Stanojević S, Micić S, Vujić V, Kovačević-Jovanović V, Mitić K, von Hoersten S, Kosec D. Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch. in Peptides. 2006;27(12):3208-3215.
doi:10.1016/j.peptides.2006.08.018
conv_109 .
Dimitrijević, Mirjana, Stanojević, Stanislava, Micić, Stana, Vujić, Vesna, Kovačević-Jovanović, Vesna, Mitić, Katarina, von Hoersten, Stephan, Kosec, Duško, "Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch" in Peptides, 27, no. 12 (2006):3208-3215,
https://doi.org/10.1016/j.peptides.2006.08.018 .,
conv_109 .
