Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch
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2006
Authors
Dimitrijević, MirjanaStanojević, Stanislava
Micić, Stana
Vujić, Vesna
Kovačević-Jovanović, Vesna
Mitić, Katarina
von Hoersten, Stephan
Kosec, Duško
Article (Published version)
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We studied the effects of neuropeptide Y (NPY) and NPY-related receptor specific peptides on functions of carrageenan-elicited granulocytes in vitro and ability of NPY to modulate carrageenan-induced air pouch inflammation in rats in vivo. Anti-inflammatory effect of NPY comprises reduced granulocyte accumulation into the air pouch, to some extent attenuation of phagocytosis, attained via Y1 receptor, and considerable decrease in peroxide production, albeit mediated via Y2 and Y5 receptors activation. Conversely, NPY increases nitric oxide production and this potentiation is mediated via Y1 receptor. It is concluded that NPY Y1 and Y2/Y5 receptors' interaction participates in NPY-induced modulation of granulocyte functions related to inflammation. (c) 2006 Elsevier Inc. All rights reserved.
Keywords:
neuropeptide y (NPY) / NPY receptors / inflammation / granulocytes ratSource:
Peptides, 2006, 27, 12, 3208-3215Publisher:
- Elsevier Science Inc, New York
Funding / projects:
DOI: 10.1016/j.peptides.2006.08.018
ISSN: 0196-9781
PubMed: 17010476
WoS: 000242821300022
Scopus: 2-s2.0-33750959354
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TorlakTY - JOUR AU - Dimitrijević, Mirjana AU - Stanojević, Stanislava AU - Micić, Stana AU - Vujić, Vesna AU - Kovačević-Jovanović, Vesna AU - Mitić, Katarina AU - von Hoersten, Stephan AU - Kosec, Duško PY - 2006 UR - http://intor.torlakinstitut.com/handle/123456789/218 AB - We studied the effects of neuropeptide Y (NPY) and NPY-related receptor specific peptides on functions of carrageenan-elicited granulocytes in vitro and ability of NPY to modulate carrageenan-induced air pouch inflammation in rats in vivo. Anti-inflammatory effect of NPY comprises reduced granulocyte accumulation into the air pouch, to some extent attenuation of phagocytosis, attained via Y1 receptor, and considerable decrease in peroxide production, albeit mediated via Y2 and Y5 receptors activation. Conversely, NPY increases nitric oxide production and this potentiation is mediated via Y1 receptor. It is concluded that NPY Y1 and Y2/Y5 receptors' interaction participates in NPY-induced modulation of granulocyte functions related to inflammation. (c) 2006 Elsevier Inc. All rights reserved. PB - Elsevier Science Inc, New York T2 - Peptides T1 - Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch EP - 3215 IS - 12 SP - 3208 VL - 27 DO - 10.1016/j.peptides.2006.08.018 ER -
@article{ author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Micić, Stana and Vujić, Vesna and Kovačević-Jovanović, Vesna and Mitić, Katarina and von Hoersten, Stephan and Kosec, Duško", year = "2006", abstract = "We studied the effects of neuropeptide Y (NPY) and NPY-related receptor specific peptides on functions of carrageenan-elicited granulocytes in vitro and ability of NPY to modulate carrageenan-induced air pouch inflammation in rats in vivo. Anti-inflammatory effect of NPY comprises reduced granulocyte accumulation into the air pouch, to some extent attenuation of phagocytosis, attained via Y1 receptor, and considerable decrease in peroxide production, albeit mediated via Y2 and Y5 receptors activation. Conversely, NPY increases nitric oxide production and this potentiation is mediated via Y1 receptor. It is concluded that NPY Y1 and Y2/Y5 receptors' interaction participates in NPY-induced modulation of granulocyte functions related to inflammation. (c) 2006 Elsevier Inc. All rights reserved.", publisher = "Elsevier Science Inc, New York", journal = "Peptides", title = "Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch", pages = "3215-3208", number = "12", volume = "27", doi = "10.1016/j.peptides.2006.08.018" }
Dimitrijević, M., Stanojević, S., Micić, S., Vujić, V., Kovačević-Jovanović, V., Mitić, K., von Hoersten, S.,& Kosec, D.. (2006). Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch. in Peptides Elsevier Science Inc, New York., 27(12), 3208-3215. https://doi.org/10.1016/j.peptides.2006.08.018
Dimitrijević M, Stanojević S, Micić S, Vujić V, Kovačević-Jovanović V, Mitić K, von Hoersten S, Kosec D. Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch. in Peptides. 2006;27(12):3208-3215. doi:10.1016/j.peptides.2006.08.018 .
Dimitrijević, Mirjana, Stanojević, Stanislava, Micić, Stana, Vujić, Vesna, Kovačević-Jovanović, Vesna, Mitić, Katarina, von Hoersten, Stephan, Kosec, Duško, "Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch" in Peptides, 27, no. 12 (2006):3208-3215, https://doi.org/10.1016/j.peptides.2006.08.018 . .