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dc.creatorMiletić, Tatjana
dc.creatorKovačević-Jovanović, Vesna
dc.creatorStanojević, Stanislava
dc.creatorVujić, Vesna
dc.creatorKosec, Duško
dc.creatorMitić, Katarina
dc.creatorDimitrijević, Mirjana
dc.date.accessioned2021-02-18T10:29:18Z
dc.date.available2021-02-18T10:29:18Z
dc.date.issued2006
dc.identifier.issn0300-9475
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/213
dc.description.abstractBecause of high sequence homology between microbial and endogenous heat shock proteins (HSP), immunological cross-reactivity to microbial HSP has been suggested as a possible cause of the development of autoimmune diseases, such as rheumatoid arthritis. The present study aimed to determine a potential role of HSP47, a molecular chaperone involved in the synthesis and assembly of collagen molecules, and microbial HSP71 (mHSP71) in adjuvant arthritis (AA) in two rat strains: Dark Agouti (DA), susceptible to AA induction and Albino Oxford (AO), which is resistant to AA induction. Immunization with complete Freund's adjuvant (CFA) induced an increased expression of HSP47 in joints of DA rats, which exhibited severe clinical signs of AA at the time of disease peak, while this protein was not detectable in joints of AO rats. In contrast, no strain differences in HSP72 (rat analogue of mHSP71) expressions in joints were observed. The increased levels of anti-HSP47 antibodies were detected in sera of DA rats during the AA peak, while the immunization with CFA increased levels of anti-mHSP71 antibodies in sera of AO rats. HSP47 and mHSP71 reduced proliferation of draining inguinal lymph node cells (LNC) in resistant AO rat strain, leading to a hypothesis that both HSP participated in AA control. Finally, mHSP71 potentiated the apoptotic response of LNC in susceptible DA rat strain. In conclusion, our findings indicate involvement of HSP47 in the development of AA in the rat, and point out to the regulatory role for both HSP47 and mHSP71.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsopenAccess
dc.sourceScandinavian Journal of Immunology
dc.titleStrain differences and the role for HSP47 and HSP70 in adjuvant arthritis in ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage632
dc.citation.issue6
dc.citation.other64(6): 623-632
dc.citation.rankM23
dc.citation.spage623
dc.citation.volume64
dc.identifier.doi10.1111/j.1365-3083.2006.01852.x
dc.identifier.fulltexthttp://intor.torlakinstitut.com/bitstream/id/87/210.pdf
dc.identifier.pmid17083618
dc.identifier.rcubconv_184
dc.identifier.scopus2-s2.0-33750709209
dc.identifier.wos000241776300006
dc.type.versionpublishedVersion


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