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dc.creatorStanojević, Stanislava
dc.creatorMitić, Katarina
dc.creatorVujić, Vesna
dc.creatorKovačević-Jovanović, Vesna
dc.creatorDimitrijević, Mirjana
dc.date.accessioned2021-02-18T10:29:13Z
dc.date.available2021-02-18T10:29:13Z
dc.date.issued2006
dc.identifier.issn0014-2999
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/212
dc.description.abstractIt has been shown that inflammation of rat paws elicits accumulation of opioid peptide is-endorphin-containing immune cells in the inflamed subcutaneous tissue, contributing to immumocyte-produced pain suppression. However, the possible mechanisms involved in the pharmacological application of beta-endorphin in rat paw inflammation have not been investigated. The present study was set up to explore the effects of intraplantar injection of beta-endorphin on Concanavalin A-induced paw edema in two inbred rat strains, Albino Oxford (AO) and Dark Agouti (DA). Both high dose-induced suppression and low dose-induced potentiation of edema development in AO and DA rats, respectively, were blocked with antagonists specific for 6 (naltrindole) and K (nor-binaltorphimine) opioid receptors. beta-endorphin in vitro decreased phagocytosis and increased nitric oxide (NO) production in air pouch granulocytes obtained from AD rats. However, in cells from DA rat strain beta-endorphin modulated both phagocytosis and NO production in a concentration-dependent manner. It could be concluded that the strain-dependent opposing effects of endorphin on paw inflammation are mediated through 6 and K opioid receptors and probably involve changes in the production of reactive oxygen species by inflammatory cells. Our results point to the importance of genotype for pharmacological manipulations and the development of inflammation. (c) 2006 Elsevier B.V. All rights reserved.en
dc.publisherElsevier, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmacology
dc.subjectpaw edemaen
dc.subjectbeta-endorphinen
dc.subjectgranulocytesen
dc.subjectphagocytosisen
dc.subjectNO (nitric oxide) productionen
dc.subjectmu, delta, kappa opioid receptorsen
dc.subjectAO (Albino Oxford) raten
dc.subjectDA (Dark Agouti) raten
dc.titlebeta-endorphin differentially affects inflammation in two inbred rat strainsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage165
dc.citation.issue1-3
dc.citation.other549(1-3): 157-165
dc.citation.rankM22
dc.citation.spage157
dc.citation.volume549
dc.identifier.doi10.1016/j.ejphar.2006.08.012
dc.identifier.pmid16978600
dc.identifier.rcubconv_183
dc.identifier.scopus2-s2.0-33748961109
dc.identifier.wos000241225700021
dc.type.versionpublishedVersion


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