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dc.creatorJovanova-Nešić, Katica
dc.creatorJanković, B.D.
dc.date.accessioned2021-02-18T10:28:33Z
dc.date.available2021-02-18T10:28:33Z
dc.date.issued2005
dc.identifier.issn0077-8923
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/202
dc.description.abstractThe ultimate goal of this report is to learn how to manipulate the level of memory T cells for more effective treatment of such neurological diseases as multiple sclerosis (MS), where certain T cell subsets recognize self-antigens as opposed to pathogen antigens, and Alzheimer's disease (AD). Brain lesions (electrolitically, by kainic acid, with AlCl, and with 6-OHDA); stimulations (electrical, magnetic, or pharmacological); or restoration of some neurological functions (thermoregulatory and behavioral) by fetal graft allotransplantations in bilaterally lesioned anterior hypothalamic area (AHA-immune regulation) and nucleus basalis magnocellularis (NBM-experimental AD) in our studies were designed to reproduce immune and cognitive deficits induced by lesions of these brain structures. To localize memory traces in the immune system and in the brain we used ethanol and drugs such as kainic acid and 6-OHDA, which have been used very effectively to produce temporary lesions in the brain. Rats showed no learning and memory ability as well as inhibition of immune reactions.en
dc.publisherNew York Acad Sciences, New York
dc.rightsrestrictedAccess
dc.sourceReversal of Aging: Resetting the Pineal Clock
dc.subjectratsen
dc.subjectbrain lesionsen
dc.subjectbrain stimulationen
dc.subjectfetal allotransplantationen
dc.subjectbehavioren
dc.subjectexperimental allergic encephalomyelitisen
dc.subjectAlzheimer's diseaseen
dc.titleThe neuronal and immune memory systems as supervisors of neural plasticity and aging of the brain - From phenomenology to coding of informationen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage295
dc.citation.other1057: 279-295
dc.citation.rankM21
dc.citation.spage279
dc.citation.volume1057
dc.identifier.doi10.1196/annals.1356.022
dc.identifier.pmid16399901
dc.identifier.rcubconv_176
dc.identifier.scopus2-s2.0-32244434515
dc.identifier.wos000236116800018
dc.type.versionpublishedVersion


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