Приказ основних података о документу

dc.creatorDimitrijević, Mirjana
dc.creatorStanojević, Stanislava
dc.creatorVujić, Vesna
dc.creatorBeck-Sickinger, A.
dc.creatorvon Hoersten, Stephan
dc.date.accessioned2021-02-18T10:28:25Z
dc.date.available2021-02-18T10:28:25Z
dc.date.issued2005
dc.identifier.issn0167-0115
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/200
dc.description.abstractIt is well documented that neuropeptide Y (NPY) exerts a wide range of biological functions through at least five NPY Y receptor subtypes (Y1-Y5), but its immunological effects only recently came into focus. Using NPY family pepticles and NPY-related receptor-specific peptides as well as Y1 and Y2 receptor antagonists, we have tested which NPY Y receptors are involved in NPY-induced modulation of rat peritoneal macrophage function in vitro. NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages. The combined treatment with NPY and NPY Y receptor antagonists revealed that NPY-induced potentiation of oxidative burst in PMA-stimulated cells is mediated through Y1 and Y2 receptors, while NPY-induced suppression in zymosan-stimulated cells is mediated through Y2 receptors only. NPY-related peptides differently modulated macrophage function, confirming involvement of NPY Y2 receptor in both potentiation and suppression of oxidative burst in these cells. Additionally, it was shown that NPY Y5 receptor mediated suppression of oxidative burst in PMA- and zymosan-stimulated macrophages. Taken together, the present data reveal an NPY Y1 and Y2/Y5 receptor interaction in NPY-induced modulation of macrophage functions related to inflammation. (C) 2004 Elsevier B.V. All rights reserved.en
dc.publisherElsevier, Amsterdam
dc.rightsrestrictedAccess
dc.sourceRegulatory Peptides
dc.subjectneuropeptide Y (NPY)en
dc.subjectNPY receptorsen
dc.subjectmacrophageen
dc.subjectoxidative bursten
dc.subjectdark agouti (DA) ratsen
dc.titleNeuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptorsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage172
dc.citation.issue1-3
dc.citation.other124(1-3): 163-172
dc.citation.rankM22
dc.citation.spage163
dc.citation.volume124
dc.identifier.doi10.1016/j.regpep.2004.07.012
dc.identifier.pmid15544855
dc.identifier.scopus2-s2.0-8444225461
dc.identifier.wos000225638300021
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу