Приказ основних података о документу

dc.creatorKosec, Duško
dc.creatorVidić-Danković, Biljana
dc.creatorIsaković, Katarina
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:28:18Z
dc.date.available2021-02-18T10:28:18Z
dc.date.issued2005
dc.identifier.issn0020-7454
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/198
dc.description.abstractExperimental autoimmune myasthenia gravis (EAMG) was induced in female AO rats, by a single immunization with Torpedo acetylcholine receptor (AChR). Animals injected with saline served as controls. The study showed substantial changes in EAMG rats in the thymopoiesis, causing an increase in the relative proportion of mature CD8+ and, particularly, CD4+ (possibly autoreactive) single positive (SP) cells expressing TCR alpha beta at high level (TCR alpha beta(high)), as well as in that of mature double negative (DN) TCR alpha beta(high) cells, which are believed to be the immunoregulatory cells that augment autoantibody (autoAb) production. These results indicate that an augmented production of autoreactive CD4+ cells, on one side, and an increase of the immunoregulatory T cells that augment autoAb production, on the other side (reflecting, most likely, an increased entry of activated autoreactive CD4+ T cells from the periphery into the thymus), may have a significant role in the sustention of immune response in EAMG, and may suggest a putative mechanism underlying the sustention of autoimmune response in acquired MG.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Neuroscience
dc.subjectexperimental autoimmune myasthenia gravisen
dc.subjectmorphometryen
dc.subjectT-cell maturationen
dc.subjectthymusen
dc.titleAlterations in the thymopoiesis in experimental autoimmune myasthenia gravisen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage477
dc.citation.issue4
dc.citation.other115(4): 461-477
dc.citation.rankM23
dc.citation.spage461
dc.citation.volume115
dc.identifier.doi10.1080/00207450590522464
dc.identifier.pmid15809214
dc.identifier.scopus2-s2.0-16244396087
dc.identifier.wos000227878100003
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу