Changes in thymopoiesis in myasthenia gravis
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2005
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This study was undertaken to investigate T-cell maturation ill hyperplastic thymi of patients suffering from myasthenia gravis (MG). For this purpose, the expression of the major differentiational molecules (CD4, CD8, and CD3/TCRalphass) and that of the regulator. v and activation molecules oil thymocytes from MG patients and control subjects were estimated by flow cytometric analysis. In the MG patients the increase in relative proportion of immature (CD4-8- TCRalphass-) and the most mature (CD4+8- TCRalphass(high) and CD4-8- TCRhigh encompassing immunoregulatory NKT) thymocytes followed by a decrease in that of CD4+8+CD3 /TCRalphass- cells was found. Furthermore, in these patients the relative proportion of CD4+HLA-DR+ and CD4+71+ cells was increased, whereas that of CD4+25+ cells was slightly, but significantly, decreased (reflecting, most likely, decreased contribution of T reg cells bearing this phenotype). Moreover. in MG thymi the percentage of CD45RA+ cells was reduced indicati...ng changes in the selection processes. In keeping with this finding the reduced thymocyte apoptotic index and percentage of cells bearing apoptosing (CD4-8- TCRalphass(low)) phenotype were detected. In conclusion, the study demonstrates substantial changes in intrathymic differentiation of T cells in hyperplastic MG thymi and suggests alterations in selection events providing an increased escape of potentially? autoreactive T-cell clones, on one side, and all altered maturation and/or selection of immunoregulatory cells (NKT and CD4+8-25+ T reg cells) keeping these cell clones under control, on the other side.
Ključne reči:
immunoregulatory cells / myasthenia gravis / T-cell maturationIzvor:
International Journal of Neuroscience, 2005, 115, 2, 223-243Izdavač:
- Taylor & Francis Ltd, Abingdon
DOI: 10.1080/00207450590519472
ISSN: 0020-7454
PubMed: 15764003
WoS: 000226305300006
Scopus: 2-s2.0-11244318428
Institucija/grupa
TorlakTY - JOUR AU - Kosec, Duško AU - Lavrnić, Dragana AU - Apostolski, Slobodan AU - Leposavić, Gordana PY - 2005 UR - http://intor.torlakinstitut.com/handle/123456789/197 AB - This study was undertaken to investigate T-cell maturation ill hyperplastic thymi of patients suffering from myasthenia gravis (MG). For this purpose, the expression of the major differentiational molecules (CD4, CD8, and CD3/TCRalphass) and that of the regulator. v and activation molecules oil thymocytes from MG patients and control subjects were estimated by flow cytometric analysis. In the MG patients the increase in relative proportion of immature (CD4-8- TCRalphass-) and the most mature (CD4+8- TCRalphass(high) and CD4-8- TCRhigh encompassing immunoregulatory NKT) thymocytes followed by a decrease in that of CD4+8+CD3 /TCRalphass- cells was found. Furthermore, in these patients the relative proportion of CD4+HLA-DR+ and CD4+71+ cells was increased, whereas that of CD4+25+ cells was slightly, but significantly, decreased (reflecting, most likely, decreased contribution of T reg cells bearing this phenotype). Moreover. in MG thymi the percentage of CD45RA+ cells was reduced indicating changes in the selection processes. In keeping with this finding the reduced thymocyte apoptotic index and percentage of cells bearing apoptosing (CD4-8- TCRalphass(low)) phenotype were detected. In conclusion, the study demonstrates substantial changes in intrathymic differentiation of T cells in hyperplastic MG thymi and suggests alterations in selection events providing an increased escape of potentially? autoreactive T-cell clones, on one side, and all altered maturation and/or selection of immunoregulatory cells (NKT and CD4+8-25+ T reg cells) keeping these cell clones under control, on the other side. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Changes in thymopoiesis in myasthenia gravis EP - 243 IS - 2 SP - 223 VL - 115 DO - 10.1080/00207450590519472 ER -
@article{ author = "Kosec, Duško and Lavrnić, Dragana and Apostolski, Slobodan and Leposavić, Gordana", year = "2005", abstract = "This study was undertaken to investigate T-cell maturation ill hyperplastic thymi of patients suffering from myasthenia gravis (MG). For this purpose, the expression of the major differentiational molecules (CD4, CD8, and CD3/TCRalphass) and that of the regulator. v and activation molecules oil thymocytes from MG patients and control subjects were estimated by flow cytometric analysis. In the MG patients the increase in relative proportion of immature (CD4-8- TCRalphass-) and the most mature (CD4+8- TCRalphass(high) and CD4-8- TCRhigh encompassing immunoregulatory NKT) thymocytes followed by a decrease in that of CD4+8+CD3 /TCRalphass- cells was found. Furthermore, in these patients the relative proportion of CD4+HLA-DR+ and CD4+71+ cells was increased, whereas that of CD4+25+ cells was slightly, but significantly, decreased (reflecting, most likely, decreased contribution of T reg cells bearing this phenotype). Moreover. in MG thymi the percentage of CD45RA+ cells was reduced indicating changes in the selection processes. In keeping with this finding the reduced thymocyte apoptotic index and percentage of cells bearing apoptosing (CD4-8- TCRalphass(low)) phenotype were detected. In conclusion, the study demonstrates substantial changes in intrathymic differentiation of T cells in hyperplastic MG thymi and suggests alterations in selection events providing an increased escape of potentially? autoreactive T-cell clones, on one side, and all altered maturation and/or selection of immunoregulatory cells (NKT and CD4+8-25+ T reg cells) keeping these cell clones under control, on the other side.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Changes in thymopoiesis in myasthenia gravis", pages = "243-223", number = "2", volume = "115", doi = "10.1080/00207450590519472" }
Kosec, D., Lavrnić, D., Apostolski, S.,& Leposavić, G.. (2005). Changes in thymopoiesis in myasthenia gravis. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 115(2), 223-243. https://doi.org/10.1080/00207450590519472
Kosec D, Lavrnić D, Apostolski S, Leposavić G. Changes in thymopoiesis in myasthenia gravis. in International Journal of Neuroscience. 2005;115(2):223-243. doi:10.1080/00207450590519472 .
Kosec, Duško, Lavrnić, Dragana, Apostolski, Slobodan, Leposavić, Gordana, "Changes in thymopoiesis in myasthenia gravis" in International Journal of Neuroscience, 115, no. 2 (2005):223-243, https://doi.org/10.1080/00207450590519472 . .