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dc.creatorŽivković, Irena
dc.creatorRakin, Ana
dc.creatorPetrović-Đergović, Danica M.
dc.creatorMiljković, B.
dc.creatorMicić, M.
dc.date.accessioned2021-02-18T10:28:05Z
dc.date.available2021-02-18T10:28:05Z
dc.date.issued2005
dc.identifier.issn0065-1281
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/195
dc.description.abstractVarious stressors induce changes in the immune system. However, it has not yet been analyzed how stressors affect thymus innervation. To examine whether chronic stress alters the morphology of the thymus by changing the nerve components of the thymus, adult mate rats, 9-weeks old, were exposed to forced swimming during 21 successive days. The animals were sacrificed by decapitation after the last session and their thymuses were used for analysis of (i) the thymus compartments, (ii) distribution patterns of monoamine-containing nerve profiles and (iii) distribution patterns of acetylcholinesterase (AChE)-containing nerve profiles. Our results show that chronic stress in rats reduces the volume of both thymus cortex and medulla, numbers of thymocytes in the deep cortex and medulla and the density of fluorescent nerve profiles, whereas it increases density of fluorescent cells. The distribution patterns of nerve profiles containing monoamine and AChE were not affected. These changes indicate that chronic stress affects thymus development and T cell maturation by altering the sympathetic nerve component. (c) 2004 Elsevier GmbH. All rights reserved.en
dc.publisherElsevier Gmbh, Munich
dc.rightsrestrictedAccess
dc.sourceActa Histochemica
dc.subjectraten
dc.subjectthymusen
dc.subjectchronic stressen
dc.subjectmorphometryen
dc.subjectnoradrenergic nerve fibersen
dc.subjectAChE-positive nerve fibersen
dc.titleThe effects of chronic stress on thymus innervation in the adult raten
dc.typearticle
dc.rights.licenseARR
dc.citation.epage458
dc.citation.issue6
dc.citation.other106(6): 449-458
dc.citation.rankM23
dc.citation.spage449
dc.citation.volume106
dc.identifier.doi10.1016/j.acthis.2004.11.002
dc.identifier.pmid15707654
dc.identifier.rcubconv_171
dc.identifier.scopus2-s2.0-13644263265
dc.identifier.wos000227722700006
dc.type.versionpublishedVersion


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