Show simple item record

dc.creatorŽivković, Irena
dc.creatorRakin, Ana
dc.creatorPetrović-Đergović, Danica M.
dc.creatorKosec, Duško
dc.creatorMićić, Mileva
dc.date.accessioned2021-02-18T10:28:01Z
dc.date.available2021-02-18T10:28:01Z
dc.date.issued2005
dc.identifier.issn0165-5728
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/194
dc.description.abstractThe aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical density of thymocytes within thymus inner cortex and medulla. However, the percentage of apoptotic cells and the level of corticosterone were significantly increased. The percentages of CD4-CD8-TCR alpha beta(low/high) and CD4-CD8+TCR alpha beta(-) thymocytes were significantly increased, while the percentage of the least mature CD4+CD8-SP TCR alpha beta(-) thymocytes was significantly decreased. These results show that recurred swimming procedure induces thymus hypotrophy and elevated percentage of DN TCR alpha beta(+) cells. (c) 2004 Elsevier B.V. All rights reserved.en
dc.publisherElsevier, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Neuroimmunology
dc.subjectstressen
dc.subjectmorphometryen
dc.subjectthymocyte subpopulationsen
dc.subjectapoptosisen
dc.subjectcorticosteroneen
dc.subjectthymusen
dc.titleExposure to forced swim stress alters morphofunctional characteristics of the rat thymusen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage86
dc.citation.issue1-2
dc.citation.other160(1-2): 77-86
dc.citation.rankM22
dc.citation.spage77
dc.citation.volume160
dc.identifier.doi10.1016/j.jneuroim.2004.11.002
dc.identifier.pmid15710460
dc.identifier.rcubconv_170
dc.identifier.scopus2-s2.0-13844265652
dc.identifier.wos000227633500010
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record