The aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical density of thymocytes within thymus inner cortex and medulla. However, the percentage of apoptotic cells and the level of corticosterone were significantly increased. The percentages of CD4-CD8-TCR alpha beta(low/high) and CD4-CD8+TCR alpha beta(-) thymocytes were significantly increased, while the percentage of the least mature CD4+CD8-SP TCR alpha beta(-) thymocytes was significantly decreased. These results show that recurred swimming procedure induces thymus hypotrophy and elevated percentage of DN TCR alpha beta(+) cells. (c) 2004 Elsevier B.V. All rights reserved.
TY - JOUR
AU - Živković, Irena
AU - Rakin, Ana
AU - Petrović-Đergović, Danica M.
AU - Kosec, Duško
AU - Mićić, Mileva
PY - 2005
UR - http://intor.torlakinstitut.com/handle/123456789/194
AB - The aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical density of thymocytes within thymus inner cortex and medulla. However, the percentage of apoptotic cells and the level of corticosterone were significantly increased. The percentages of CD4-CD8-TCR alpha beta(low/high) and CD4-CD8+TCR alpha beta(-) thymocytes were significantly increased, while the percentage of the least mature CD4+CD8-SP TCR alpha beta(-) thymocytes was significantly decreased. These results show that recurred swimming procedure induces thymus hypotrophy and elevated percentage of DN TCR alpha beta(+) cells. (c) 2004 Elsevier B.V. All rights reserved.
PB - Elsevier, Amsterdam
T2 - Journal of Neuroimmunology
T1 - Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus
EP - 86
IS - 1-2
SP - 77
VL - 160
DO - 10.1016/j.jneuroim.2004.11.002
ER -
@article{
author = "Živković, Irena and Rakin, Ana and Petrović-Đergović, Danica M. and Kosec, Duško and Mićić, Mileva",
year = "2005",
url = "http://intor.torlakinstitut.com/handle/123456789/194",
abstract = "The aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical density of thymocytes within thymus inner cortex and medulla. However, the percentage of apoptotic cells and the level of corticosterone were significantly increased. The percentages of CD4-CD8-TCR alpha beta(low/high) and CD4-CD8+TCR alpha beta(-) thymocytes were significantly increased, while the percentage of the least mature CD4+CD8-SP TCR alpha beta(-) thymocytes was significantly decreased. These results show that recurred swimming procedure induces thymus hypotrophy and elevated percentage of DN TCR alpha beta(+) cells. (c) 2004 Elsevier B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Neuroimmunology",
title = "Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus",
pages = "86-77",
number = "1-2",
volume = "160",
doi = "10.1016/j.jneuroim.2004.11.002"
}
Živković, I., Rakin, A., Petrović-Đergović, D. M., Kosec, D.,& Mićić, M. (2005). Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus.
Journal of Neuroimmunology
Elsevier, Amsterdam., 160(1-2), 77-86.
https://doi.org/10.1016/j.jneuroim.2004.11.002
Živković I, Rakin A, Petrović-Đergović DM, Kosec D, Mićić M. Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus. Journal of Neuroimmunology. 2005;160(1-2):77-86
Živković Irena, Rakin Ana, Petrović-Đergović Danica M., Kosec Duško, Mićić Mileva, "Exposure to forced swim stress alters morphofunctional characteristics of the rat thymus" Journal of Neuroimmunology, 160, no. 1-2 (2005):77-86,
https://doi.org/10.1016/j.jneuroim.2004.11.002 .
