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dc.creatorLeposavić, Gordana
dc.creatorPekić, S.
dc.creatorKosec, Duško
dc.date.accessioned2021-02-18T10:27:52Z
dc.date.available2021-02-18T10:27:52Z
dc.date.issued2005
dc.identifier.issn1046-7408
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/192
dc.description.abstractPROBLEM: In addition to having an indirect effect on the T-cell development by controlling the production of ovarian steroids, an accumulating body of evidence suggest that GnRH analogue (GnRH-A) administration may exert a thymopoietic regulatory effect that is not mediated by ovarian hormones. METHOD OF STUDY: In non-ovariectomized (non-OVX) and OVX adult female AO rats treated s.c. with GnRH-A or saline (controls), over 14 days, were estimated the thymic cellularity and thymocyte expression of CD4/CD8/TCRalphabeta by stereological analysis and three-color flow cytometry, respectively. RESULTS: GnRH-A in both groups of rats diminished the thymic cellularity. In non-OVX rats GnRH-A increased the relative numbers of immature cells (CD4-8-TCRalphabeta(-), CD4-8-TCRalphabeta(low) and CD4+8-TCRalphabeta(low)), and reduced those of positively selected CD4+8+TCRalphabeta(high) and mature (CD4-8+TCRalphabeta(high), CD4+8-TCRalphabeta(high)) cells, suggesting decelerated expression of TCRalphabeta followed by less efficient positive selection and further maturation of the selected cells. Differently, in OVX rats GnRH-A decreased the percentage of immature (CD4-8-TCRalphabeta(-), CD4+8+ TCRalphabeta(-)) cells and increased those of all TCRalphabeta(high) subsets, suggesting an increased rate of early thymocyte differentiation, more efficient positive selection and further maturation of the selected cells. CONCLUSIONS: The effect of GnRH-A administration is affected by the presence of ovarian steroids.en
dc.publisherWiley, Hoboken
dc.rightsrestrictedAccess
dc.sourceAmerican Journal of Reproductive Immunology
dc.subjectdistribution of thymocyte subsetsen
dc.subjectGnRH agonist chronic treatmenten
dc.subjectthymic cellularityen
dc.titleGonadotropin-releasing hormone agonist administration affects the thymopoiesis in adult female rats independently on gonadal hormone productionen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage41
dc.citation.issue1
dc.citation.other53(1): 30-41
dc.citation.rankM23
dc.citation.spage30
dc.citation.volume53
dc.identifier.doi10.1111/j.1600-0897.2004.00244.x
dc.identifier.pmid15667523
dc.identifier.rcubconv_166
dc.identifier.scopus2-s2.0-13844266205
dc.identifier.wos000226513500004
dc.type.versionpublishedVersion


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