In this paper we report data regarding the IgM Y7 cross-reactive idiotope (CRIo) obtained by analysis of: 1) its V-gene subgroup dependance, 2) the frequency of its expression on human monoclonal IgMs and IgM molecules from normal and pathological sera. Furthermore, comparison of epitopic repertoire and nature of binding of human monoclonal IgMs expressing Y7 CRIo was performed to confirm the natural antibody properties of these molecules. IgM isolated from sera of patient DJ (IgM DJ) which expresses the Y7 idiotope has been classified to V(H)3/V(L)2 subgroup. From ten IgMs tested only IgM from patient RD (IgM RD) has been shown to express Y7 idiotope. Y7(+) human IgMs bound to ssDNA, lactic acid bacteria, mouse laminin, porcine thyroglobulin and mouse IgG. Higher percentage of the expression of Y7 CRIo was detected in the sera of patients suffering from autoimmune diseases such as lupus, rheumatoid arthritis and psoriasis vulgaris as well as in patients suffering from chronic infectio...ns of the lower urinary tract. Antigen binding repertoire and properties of Y7(+) monoclonal IgM, frequency of Y7 expression on monoclonal IgMs and its concentration in normal and pathological sera indicate the important biological role of this CRIo within the immune system.
TY - JOUR
AU - Dimitrijević, Ljiljana
AU - Stojanović, M.
AU - Cirić, B.
AU - Radulović, M.
AU - Stojanović, R.
AU - Popović, Zoran
AU - Inić-Kanada, Aleksandra
AU - Živković, Irena
PY - 2004
UR - http://intor.torlakinstitut.com/handle/123456789/178
AB - In this paper we report data regarding the IgM Y7 cross-reactive idiotope (CRIo) obtained by analysis of: 1) its V-gene subgroup dependance, 2) the frequency of its expression on human monoclonal IgMs and IgM molecules from normal and pathological sera. Furthermore, comparison of epitopic repertoire and nature of binding of human monoclonal IgMs expressing Y7 CRIo was performed to confirm the natural antibody properties of these molecules. IgM isolated from sera of patient DJ (IgM DJ) which expresses the Y7 idiotope has been classified to V(H)3/V(L)2 subgroup. From ten IgMs tested only IgM from patient RD (IgM RD) has been shown to express Y7 idiotope. Y7(+) human IgMs bound to ssDNA, lactic acid bacteria, mouse laminin, porcine thyroglobulin and mouse IgG. Higher percentage of the expression of Y7 CRIo was detected in the sera of patients suffering from autoimmune diseases such as lupus, rheumatoid arthritis and psoriasis vulgaris as well as in patients suffering from chronic infections of the lower urinary tract. Antigen binding repertoire and properties of Y7(+) monoclonal IgM, frequency of Y7 expression on monoclonal IgMs and its concentration in normal and pathological sera indicate the important biological role of this CRIo within the immune system.
PB - Taylor & Francis Inc, Philadelphia
T2 - Immunological Investigations
T1 - Expression of Y7 cross-reactive idiotope on human IgM molecules
EP - 14
IS - 1
SP - 1
VL - 33
DO - 10.1081/IMM-120027680
UR - conv_146
ER -
@article{
author = "Dimitrijević, Ljiljana and Stojanović, M. and Cirić, B. and Radulović, M. and Stojanović, R. and Popović, Zoran and Inić-Kanada, Aleksandra and Živković, Irena",
year = "2004",
abstract = "In this paper we report data regarding the IgM Y7 cross-reactive idiotope (CRIo) obtained by analysis of: 1) its V-gene subgroup dependance, 2) the frequency of its expression on human monoclonal IgMs and IgM molecules from normal and pathological sera. Furthermore, comparison of epitopic repertoire and nature of binding of human monoclonal IgMs expressing Y7 CRIo was performed to confirm the natural antibody properties of these molecules. IgM isolated from sera of patient DJ (IgM DJ) which expresses the Y7 idiotope has been classified to V(H)3/V(L)2 subgroup. From ten IgMs tested only IgM from patient RD (IgM RD) has been shown to express Y7 idiotope. Y7(+) human IgMs bound to ssDNA, lactic acid bacteria, mouse laminin, porcine thyroglobulin and mouse IgG. Higher percentage of the expression of Y7 CRIo was detected in the sera of patients suffering from autoimmune diseases such as lupus, rheumatoid arthritis and psoriasis vulgaris as well as in patients suffering from chronic infections of the lower urinary tract. Antigen binding repertoire and properties of Y7(+) monoclonal IgM, frequency of Y7 expression on monoclonal IgMs and its concentration in normal and pathological sera indicate the important biological role of this CRIo within the immune system.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Immunological Investigations",
title = "Expression of Y7 cross-reactive idiotope on human IgM molecules",
pages = "14-1",
number = "1",
volume = "33",
doi = "10.1081/IMM-120027680",
url = "conv_146"
}
Dimitrijević, L., Stojanović, M., Cirić, B., Radulović, M., Stojanović, R., Popović, Z., Inić-Kanada, A.,& Živković, I.. (2004). Expression of Y7 cross-reactive idiotope on human IgM molecules. in Immunological Investigations
Taylor & Francis Inc, Philadelphia., 33(1), 1-14.
https://doi.org/10.1081/IMM-120027680
conv_146
Dimitrijević L, Stojanović M, Cirić B, Radulović M, Stojanović R, Popović Z, Inić-Kanada A, Živković I. Expression of Y7 cross-reactive idiotope on human IgM molecules. in Immunological Investigations. 2004;33(1):1-14.
doi:10.1081/IMM-120027680
conv_146 .
Dimitrijević, Ljiljana, Stojanović, M., Cirić, B., Radulović, M., Stojanović, R., Popović, Zoran, Inić-Kanada, Aleksandra, Živković, Irena, "Expression of Y7 cross-reactive idiotope on human IgM molecules" in Immunological Investigations, 33, no. 1 (2004):1-14,
https://doi.org/10.1081/IMM-120027680 .,
conv_146 .
