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The possible role of natural idiotopes in immune memory

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2004
174.pdf (1.165Mb)
Authors
Dimitrijević, Ljiljana
Živančević-Simonović, Snežana
Stojanović, Marijana
Inić-Kanada, Aleksandra
Živković, Irena
Conference object (Published version)
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Abstract
In this paper we report on the generation of Abs possessing specificities similar to those of Abs used in immunization, and on the generation of Id and anti-Id specificities in the sera of mice immunized with commensal bacterial antigens. The human monoclonal antibody IgM DJ (VH3/VL2) expresses natural antibody properties, natural idiotope (Y7), and specificity towards Lactic acid bacteria (LAB). When used in immunization it generates LAB-specific antibodies. Immunization with LAB, as detected in the presence of biotin-labelled mouse monoclonal anti-idiotopic antibodies Y7 and IgM DJ generates Absl and Abs2, respectively. These findings may imply that the recognition of bacterial motifs accords with the rules of idiotypic network theory. This theory, first proposed by Jerne in 1974 and often overlooked since, has been subject to change during the course of immunological research. Recent experiments concerning the recognition of bacterial motifs and natural memory in the immune system h...ave inspired us in our attempt at explaining the possible role of natural Id in immune memory.

Keywords:
Anti-Id / Idiotope / Natural memory / Network
Source:
Clinical and Developmental Immunology, 2004, 11, 3-4, 281-285
Publisher:
  • Taylor and Francis Ltd.

DOI: 10.1080/17402520400001645

ISSN: 1740-2522

PubMed: 15559375

Scopus: 2-s2.0-7244234571
[ Google Scholar ]
3
URI
http://intor.torlakinstitut.com/handle/123456789/177
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - CONF
AU  - Dimitrijević, Ljiljana
AU  - Živančević-Simonović, Snežana
AU  - Stojanović, Marijana
AU  - Inić-Kanada, Aleksandra
AU  - Živković, Irena
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/177
AB  - In this paper we report on the generation of Abs possessing specificities similar to those of Abs used in immunization, and on the generation of Id and anti-Id specificities in the sera of mice immunized with commensal bacterial antigens. The human monoclonal antibody IgM DJ (VH3/VL2) expresses natural antibody properties, natural idiotope (Y7), and specificity towards Lactic acid bacteria (LAB). When used in immunization it generates LAB-specific antibodies. Immunization with LAB, as detected in the presence of biotin-labelled mouse monoclonal anti-idiotopic antibodies Y7 and IgM DJ generates Absl and Abs2, respectively. These findings may imply that the recognition of bacterial motifs accords with the rules of idiotypic network theory. This theory, first proposed by Jerne in 1974 and often overlooked since, has been subject to change during the course of immunological research. Recent experiments concerning the recognition of bacterial motifs and natural memory in the immune system have inspired us in our attempt at explaining the possible role of natural Id in immune memory.
PB  - Taylor and Francis Ltd.
C3  - Clinical and Developmental Immunology
T1  - The possible role of natural idiotopes in immune memory
EP  - 285
IS  - 3-4
SP  - 281
VL  - 11
DO  - 10.1080/17402520400001645
UR  - conv_562
ER  - 
@conference{
author = "Dimitrijević, Ljiljana and Živančević-Simonović, Snežana and Stojanović, Marijana and Inić-Kanada, Aleksandra and Živković, Irena",
year = "2004",
abstract = "In this paper we report on the generation of Abs possessing specificities similar to those of Abs used in immunization, and on the generation of Id and anti-Id specificities in the sera of mice immunized with commensal bacterial antigens. The human monoclonal antibody IgM DJ (VH3/VL2) expresses natural antibody properties, natural idiotope (Y7), and specificity towards Lactic acid bacteria (LAB). When used in immunization it generates LAB-specific antibodies. Immunization with LAB, as detected in the presence of biotin-labelled mouse monoclonal anti-idiotopic antibodies Y7 and IgM DJ generates Absl and Abs2, respectively. These findings may imply that the recognition of bacterial motifs accords with the rules of idiotypic network theory. This theory, first proposed by Jerne in 1974 and often overlooked since, has been subject to change during the course of immunological research. Recent experiments concerning the recognition of bacterial motifs and natural memory in the immune system have inspired us in our attempt at explaining the possible role of natural Id in immune memory.",
publisher = "Taylor and Francis Ltd.",
journal = "Clinical and Developmental Immunology",
title = "The possible role of natural idiotopes in immune memory",
pages = "285-281",
number = "3-4",
volume = "11",
doi = "10.1080/17402520400001645",
url = "conv_562"
}
Dimitrijević, L., Živančević-Simonović, S., Stojanović, M., Inić-Kanada, A.,& Živković, I.. (2004). The possible role of natural idiotopes in immune memory. in Clinical and Developmental Immunology
Taylor and Francis Ltd.., 11(3-4), 281-285.
https://doi.org/10.1080/17402520400001645
conv_562
Dimitrijević L, Živančević-Simonović S, Stojanović M, Inić-Kanada A, Živković I. The possible role of natural idiotopes in immune memory. in Clinical and Developmental Immunology. 2004;11(3-4):281-285.
doi:10.1080/17402520400001645
conv_562 .
Dimitrijević, Ljiljana, Živančević-Simonović, Snežana, Stojanović, Marijana, Inić-Kanada, Aleksandra, Živković, Irena, "The possible role of natural idiotopes in immune memory" in Clinical and Developmental Immunology, 11, no. 3-4 (2004):281-285,
https://doi.org/10.1080/17402520400001645 .,
conv_562 .

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