Drug hypersensitivity syndrome is a severe form of hypersensitivity to the antiepileptic agent carbamazepine, particularly in presence of visceral and hematological manifestations that must be evidenced and treated in time. Two cases of female patients with carbamazepine-induced hypersensitivity syndrome are reported. Both patients had prominent general complaints (febricity, weakness). The first patient had leukopenia, lymphadenopathy and rash, while the other one had urticaria, angioedema and hepatitis after administration of carbamazepine. Hypersensitivity reactions induced by antiepileptics widely applied in the practice may be severe and life-threatening if blood elements are involved via the immune or nonimmune mechanisms and if they result in hepatitis.
TY - JOUR
AU - Bogić, Mirjana
AU - Rašković, S.
AU - Sojić, J.
AU - Boricić, I.
AU - Ješić, R.
AU - Burazer, Lidija
AU - Spirić, V.T.
AU - Popadić, A.P.
AU - Đurić, V.
AU - Celeketić, D.
PY - 2004
UR - http://intor.torlakinstitut.com/handle/123456789/174
AB - Drug hypersensitivity syndrome is a severe form of hypersensitivity to the antiepileptic agent carbamazepine, particularly in presence of visceral and hematological manifestations that must be evidenced and treated in time. Two cases of female patients with carbamazepine-induced hypersensitivity syndrome are reported. Both patients had prominent general complaints (febricity, weakness). The first patient had leukopenia, lymphadenopathy and rash, while the other one had urticaria, angioedema and hepatitis after administration of carbamazepine. Hypersensitivity reactions induced by antiepileptics widely applied in the practice may be severe and life-threatening if blood elements are involved via the immune or nonimmune mechanisms and if they result in hepatitis.
PB - Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen
T2 - Allergologie
T1 - Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases
EP - 472
IS - 11
SP - 468
VL - 27
DO - 10.5414/ALP27468
ER -
@article{
author = "Bogić, Mirjana and Rašković, S. and Sojić, J. and Boricić, I. and Ješić, R. and Burazer, Lidija and Spirić, V.T. and Popadić, A.P. and Đurić, V. and Celeketić, D.",
year = "2004",
url = "http://intor.torlakinstitut.com/handle/123456789/174",
abstract = "Drug hypersensitivity syndrome is a severe form of hypersensitivity to the antiepileptic agent carbamazepine, particularly in presence of visceral and hematological manifestations that must be evidenced and treated in time. Two cases of female patients with carbamazepine-induced hypersensitivity syndrome are reported. Both patients had prominent general complaints (febricity, weakness). The first patient had leukopenia, lymphadenopathy and rash, while the other one had urticaria, angioedema and hepatitis after administration of carbamazepine. Hypersensitivity reactions induced by antiepileptics widely applied in the practice may be severe and life-threatening if blood elements are involved via the immune or nonimmune mechanisms and if they result in hepatitis.",
publisher = "Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen",
journal = "Allergologie",
title = "Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases",
pages = "472-468",
number = "11",
volume = "27",
doi = "10.5414/ALP27468"
}
Bogić, M., Rašković, S., Sojić, J., Boricić, I., Ješić, R., Burazer, L., Spirić, V.T., Popadić, A.P., Đurić, V.,& Celeketić, D. (2004). Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases.
Allergologie
Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen., 27(11), 468-472.
https://doi.org/10.5414/ALP27468
Bogić M, Rašković S, Sojić J, Boricić I, Ješić R, Burazer L, Spirić V, Popadić A, Đurić V, Celeketić D. Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases. Allergologie. 2004;27(11):468-472
Bogić Mirjana, Rašković S., Sojić J., Boricić I., Ješić R., Burazer Lidija, Spirić V.T., Popadić A.P., Đurić V., Celeketić D., "Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases" Allergologie, 27, no. 11 (2004):468-472,
https://doi.org/10.5414/ALP27468 .
