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Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases

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Authors
Bogić, Mirjana
Rašković, S.
Sojić, J.
Boricić, I.
Ješić, R.
Burazer, Lidija
Spirić, V.T.
Popadić, A.P.
Đurić, V.
Celeketić, D.
Article (Published version)
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Abstract
Drug hypersensitivity syndrome is a severe form of hypersensitivity to the antiepileptic agent carbamazepine, particularly in presence of visceral and hematological manifestations that must be evidenced and treated in time. Two cases of female patients with carbamazepine-induced hypersensitivity syndrome are reported. Both patients had prominent general complaints (febricity, weakness). The first patient had leukopenia, lymphadenopathy and rash, while the other one had urticaria, angioedema and hepatitis after administration of carbamazepine. Hypersensitivity reactions induced by antiepileptics widely applied in the practice may be severe and life-threatening if blood elements are involved via the immune or nonimmune mechanisms and if they result in hepatitis.
Keywords:
hypersensitivity syndrome / carbamazepine / leukopenia / hepatitis / skin rash / lymphadenopathy
Source:
Allergologie, 2004, 27, 11, 468-472
Publisher:
  • Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen

DOI: 10.5414/ALP27468

ISSN: 0344-5062

WoS: 000225548200005

Scopus: 2-s2.0-10344233168
[ Google Scholar ]
URI
http://intor.torlakinstitut.com/handle/123456789/174
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - JOUR
AU  - Bogić, Mirjana
AU  - Rašković, S.
AU  - Sojić, J.
AU  - Boricić, I.
AU  - Ješić, R.
AU  - Burazer, Lidija
AU  - Spirić, V.T.
AU  - Popadić, A.P.
AU  - Đurić, V.
AU  - Celeketić, D.
PY  - 2004
UR  - http://intor.torlakinstitut.com/handle/123456789/174
AB  - Drug hypersensitivity syndrome is a severe form of hypersensitivity to the antiepileptic agent carbamazepine, particularly in presence of visceral and hematological manifestations that must be evidenced and treated in time. Two cases of female patients with carbamazepine-induced hypersensitivity syndrome are reported. Both patients had prominent general complaints (febricity, weakness). The first patient had leukopenia, lymphadenopathy and rash, while the other one had urticaria, angioedema and hepatitis after administration of carbamazepine. Hypersensitivity reactions induced by antiepileptics widely applied in the practice may be severe and life-threatening if blood elements are involved via the immune or nonimmune mechanisms and if they result in hepatitis.
PB  - Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen
T2  - Allergologie
T1  - Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases
EP  - 472
IS  - 11
SP  - 468
VL  - 27
DO  - 10.5414/ALP27468
UR  - conv_162
ER  - 
@article{
author = "Bogić, Mirjana and Rašković, S. and Sojić, J. and Boricić, I. and Ješić, R. and Burazer, Lidija and Spirić, V.T. and Popadić, A.P. and Đurić, V. and Celeketić, D.",
year = "2004",
abstract = "Drug hypersensitivity syndrome is a severe form of hypersensitivity to the antiepileptic agent carbamazepine, particularly in presence of visceral and hematological manifestations that must be evidenced and treated in time. Two cases of female patients with carbamazepine-induced hypersensitivity syndrome are reported. Both patients had prominent general complaints (febricity, weakness). The first patient had leukopenia, lymphadenopathy and rash, while the other one had urticaria, angioedema and hepatitis after administration of carbamazepine. Hypersensitivity reactions induced by antiepileptics widely applied in the practice may be severe and life-threatening if blood elements are involved via the immune or nonimmune mechanisms and if they result in hepatitis.",
publisher = "Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen",
journal = "Allergologie",
title = "Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases",
pages = "472-468",
number = "11",
volume = "27",
doi = "10.5414/ALP27468",
url = "conv_162"
}
Bogić, M., Rašković, S., Sojić, J., Boricić, I., Ješić, R., Burazer, L., Spirić, V.T., Popadić, A.P., Đurić, V.,& Celeketić, D.. (2004). Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases. in Allergologie
Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen., 27(11), 468-472.
https://doi.org/10.5414/ALP27468
conv_162
Bogić M, Rašković S, Sojić J, Boricić I, Ješić R, Burazer L, Spirić V, Popadić A, Đurić V, Celeketić D. Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases. in Allergologie. 2004;27(11):468-472.
doi:10.5414/ALP27468
conv_162 .
Bogić, Mirjana, Rašković, S., Sojić, J., Boricić, I., Ješić, R., Burazer, Lidija, Spirić, V.T., Popadić, A.P., Đurić, V., Celeketić, D., "Carbamazepine hypersensitivity syndrome with leukopenia and hepatitis - report of two cases" in Allergologie, 27, no. 11 (2004):468-472,
https://doi.org/10.5414/ALP27468 .,
conv_162 .

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