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dc.creatorStojanović, Marijana
dc.creatorInić-Kanada, Aleksandra
dc.creatorPopović, Zoran
dc.creatorŽivković, Irena
dc.creatorDimitrijević, Ljiljana
dc.date.accessioned2021-02-18T10:26:17Z
dc.date.available2021-02-18T10:26:17Z
dc.date.issued2004
dc.identifier.issn0165-2478
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/170
dc.description.abstractAntibodies (Abs) (IgM, IgA IgG and IgG subclasses) specific for several uropathogenic strains (Escherichia coli, Pseudomonas sp. and Klebsiella sp.) as well as anti-phospholipids, anti-beta(2)-glycoprotein I and anti-laminin antibodies were analyzed in the sera of 20 patients with long-lasting uncomplicated recurrent infections of the lower urinary tract who underwent immunization treatment with a mixture of heat-inactivated bacteria. Immunization had a dual effect: a marked prolongation of the infection-free period in more than half of tested patients (which could be related to the profiles of anti-bacterial antibodies), and the induction of a significant decrease in autoreactivity. The results obtained showed that prolonged infections resulted in a significant rise in IgG specific for phospholipids, beta(2)-glycoprotein I and mouse laminin. However, irrespective of the effect on urinary tract infection per se, immunization induced a noticeable decrease in reactivity toward those antigens (Ag). The most abundant autoantibodies prior to immunization treatment were of IgG2 subclass. A statistically significant decrease in phospholipid specific antibodies belonging to this subclass, and in the concentration of Y7 cross-reactive idiotope, registered only in the responder group: this indicates the significance of natural antibody pool involvement in a proper anti-bacterial immune response. (C) 2004 Elsevier B.V. All rights reserved.en
dc.publisherElsevier, Amsterdam
dc.rightsrestrictedAccess
dc.sourceImmunology Letters
dc.subjectautoantibodiesen
dc.subjectbacterial infectionen
dc.subjectcross-reactive idiotopeen
dc.subjectimmunizationen
dc.titleChanges in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatmenten
dc.typearticle
dc.rights.licenseARR
dc.citation.epage133
dc.citation.issue1-2
dc.citation.other94(1-2): 123-133
dc.citation.rankM22
dc.citation.spage123
dc.citation.volume94
dc.identifier.doi10.1016/j.imlet.2004.04.011
dc.identifier.pmid15234544
dc.identifier.rcubconv_152
dc.identifier.scopus2-s2.0-3242716138
dc.identifier.wos000222819300016
dc.type.versionpublishedVersion


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