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Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment
dc.creator | Stojanović, Marijana | |
dc.creator | Inić-Kanada, Aleksandra | |
dc.creator | Popović, Zoran | |
dc.creator | Živković, Irena | |
dc.creator | Dimitrijević, Ljiljana | |
dc.date.accessioned | 2021-02-18T10:26:17Z | |
dc.date.available | 2021-02-18T10:26:17Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0165-2478 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/170 | |
dc.description.abstract | Antibodies (Abs) (IgM, IgA IgG and IgG subclasses) specific for several uropathogenic strains (Escherichia coli, Pseudomonas sp. and Klebsiella sp.) as well as anti-phospholipids, anti-beta(2)-glycoprotein I and anti-laminin antibodies were analyzed in the sera of 20 patients with long-lasting uncomplicated recurrent infections of the lower urinary tract who underwent immunization treatment with a mixture of heat-inactivated bacteria. Immunization had a dual effect: a marked prolongation of the infection-free period in more than half of tested patients (which could be related to the profiles of anti-bacterial antibodies), and the induction of a significant decrease in autoreactivity. The results obtained showed that prolonged infections resulted in a significant rise in IgG specific for phospholipids, beta(2)-glycoprotein I and mouse laminin. However, irrespective of the effect on urinary tract infection per se, immunization induced a noticeable decrease in reactivity toward those antigens (Ag). The most abundant autoantibodies prior to immunization treatment were of IgG2 subclass. A statistically significant decrease in phospholipid specific antibodies belonging to this subclass, and in the concentration of Y7 cross-reactive idiotope, registered only in the responder group: this indicates the significance of natural antibody pool involvement in a proper anti-bacterial immune response. (C) 2004 Elsevier B.V. All rights reserved. | en |
dc.publisher | Elsevier, Amsterdam | |
dc.rights | restrictedAccess | |
dc.source | Immunology Letters | |
dc.subject | autoantibodies | en |
dc.subject | bacterial infection | en |
dc.subject | cross-reactive idiotope | en |
dc.subject | immunization | en |
dc.title | Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 133 | |
dc.citation.issue | 1-2 | |
dc.citation.other | 94(1-2): 123-133 | |
dc.citation.rank | M22 | |
dc.citation.spage | 123 | |
dc.citation.volume | 94 | |
dc.identifier.doi | 10.1016/j.imlet.2004.04.011 | |
dc.identifier.pmid | 15234544 | |
dc.identifier.scopus | 2-s2.0-3242716138 | |
dc.identifier.wos | 000222819300016 | |
dc.type.version | publishedVersion |