Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment
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2004
Authors
Stojanović, MarijanaInić-Kanada, Aleksandra
Popović, Zoran
Živković, Irena
Dimitrijević, Ljiljana
Article (Published version)
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Antibodies (Abs) (IgM, IgA IgG and IgG subclasses) specific for several uropathogenic strains (Escherichia coli, Pseudomonas sp. and Klebsiella sp.) as well as anti-phospholipids, anti-beta(2)-glycoprotein I and anti-laminin antibodies were analyzed in the sera of 20 patients with long-lasting uncomplicated recurrent infections of the lower urinary tract who underwent immunization treatment with a mixture of heat-inactivated bacteria. Immunization had a dual effect: a marked prolongation of the infection-free period in more than half of tested patients (which could be related to the profiles of anti-bacterial antibodies), and the induction of a significant decrease in autoreactivity. The results obtained showed that prolonged infections resulted in a significant rise in IgG specific for phospholipids, beta(2)-glycoprotein I and mouse laminin. However, irrespective of the effect on urinary tract infection per se, immunization induced a noticeable decrease in reactivity toward those anti...gens (Ag). The most abundant autoantibodies prior to immunization treatment were of IgG2 subclass. A statistically significant decrease in phospholipid specific antibodies belonging to this subclass, and in the concentration of Y7 cross-reactive idiotope, registered only in the responder group: this indicates the significance of natural antibody pool involvement in a proper anti-bacterial immune response. (C) 2004 Elsevier B.V. All rights reserved.
Keywords:
autoantibodies / bacterial infection / cross-reactive idiotope / immunizationSource:
Immunology Letters, 2004, 94, 1-2, 123-133Publisher:
- Elsevier, Amsterdam
DOI: 10.1016/j.imlet.2004.04.011
ISSN: 0165-2478
PubMed: 15234544
WoS: 000222819300016
Scopus: 2-s2.0-3242716138
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TorlakTY - JOUR AU - Stojanović, Marijana AU - Inić-Kanada, Aleksandra AU - Popović, Zoran AU - Živković, Irena AU - Dimitrijević, Ljiljana PY - 2004 UR - http://intor.torlakinstitut.com/handle/123456789/170 AB - Antibodies (Abs) (IgM, IgA IgG and IgG subclasses) specific for several uropathogenic strains (Escherichia coli, Pseudomonas sp. and Klebsiella sp.) as well as anti-phospholipids, anti-beta(2)-glycoprotein I and anti-laminin antibodies were analyzed in the sera of 20 patients with long-lasting uncomplicated recurrent infections of the lower urinary tract who underwent immunization treatment with a mixture of heat-inactivated bacteria. Immunization had a dual effect: a marked prolongation of the infection-free period in more than half of tested patients (which could be related to the profiles of anti-bacterial antibodies), and the induction of a significant decrease in autoreactivity. The results obtained showed that prolonged infections resulted in a significant rise in IgG specific for phospholipids, beta(2)-glycoprotein I and mouse laminin. However, irrespective of the effect on urinary tract infection per se, immunization induced a noticeable decrease in reactivity toward those antigens (Ag). The most abundant autoantibodies prior to immunization treatment were of IgG2 subclass. A statistically significant decrease in phospholipid specific antibodies belonging to this subclass, and in the concentration of Y7 cross-reactive idiotope, registered only in the responder group: this indicates the significance of natural antibody pool involvement in a proper anti-bacterial immune response. (C) 2004 Elsevier B.V. All rights reserved. PB - Elsevier, Amsterdam T2 - Immunology Letters T1 - Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment EP - 133 IS - 1-2 SP - 123 VL - 94 DO - 10.1016/j.imlet.2004.04.011 ER -
@article{ author = "Stojanović, Marijana and Inić-Kanada, Aleksandra and Popović, Zoran and Živković, Irena and Dimitrijević, Ljiljana", year = "2004", abstract = "Antibodies (Abs) (IgM, IgA IgG and IgG subclasses) specific for several uropathogenic strains (Escherichia coli, Pseudomonas sp. and Klebsiella sp.) as well as anti-phospholipids, anti-beta(2)-glycoprotein I and anti-laminin antibodies were analyzed in the sera of 20 patients with long-lasting uncomplicated recurrent infections of the lower urinary tract who underwent immunization treatment with a mixture of heat-inactivated bacteria. Immunization had a dual effect: a marked prolongation of the infection-free period in more than half of tested patients (which could be related to the profiles of anti-bacterial antibodies), and the induction of a significant decrease in autoreactivity. The results obtained showed that prolonged infections resulted in a significant rise in IgG specific for phospholipids, beta(2)-glycoprotein I and mouse laminin. However, irrespective of the effect on urinary tract infection per se, immunization induced a noticeable decrease in reactivity toward those antigens (Ag). The most abundant autoantibodies prior to immunization treatment were of IgG2 subclass. A statistically significant decrease in phospholipid specific antibodies belonging to this subclass, and in the concentration of Y7 cross-reactive idiotope, registered only in the responder group: this indicates the significance of natural antibody pool involvement in a proper anti-bacterial immune response. (C) 2004 Elsevier B.V. All rights reserved.", publisher = "Elsevier, Amsterdam", journal = "Immunology Letters", title = "Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment", pages = "133-123", number = "1-2", volume = "94", doi = "10.1016/j.imlet.2004.04.011" }
Stojanović, M., Inić-Kanada, A., Popović, Z., Živković, I.,& Dimitrijević, L.. (2004). Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment. in Immunology Letters Elsevier, Amsterdam., 94(1-2), 123-133. https://doi.org/10.1016/j.imlet.2004.04.011
Stojanović M, Inić-Kanada A, Popović Z, Živković I, Dimitrijević L. Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment. in Immunology Letters. 2004;94(1-2):123-133. doi:10.1016/j.imlet.2004.04.011 .
Stojanović, Marijana, Inić-Kanada, Aleksandra, Popović, Zoran, Živković, Irena, Dimitrijević, Ljiljana, "Changes in pools of autoantibodies and anti-bacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment" in Immunology Letters, 94, no. 1-2 (2004):123-133, https://doi.org/10.1016/j.imlet.2004.04.011 . .