Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides
Аутори
Stanojević, StanislavaDimitrijević, Mirjana
Kovačević-Jovanović, Vesna
Miletić, Tatjana
Vujić, Vesna
Radulović, Jelena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The effect of unpredictable, inescapable and uncontrollable electric tail shocks (ES) on the humoral immune response to bovine serum albumin (BSA) was investigated in the rat. Contributions of the procedures that accompany shock delivery, such as witnessing the ES procedure (stress witnessing, SW) and exposure to the apparatus for shock delivery (apparatus control, AC) to the changes in specific immunity induced by ES were also tested. All procedures were applied during primary and/or secondary immunization. It was demonstrated that exposure to ES during primary immunization with BSA significantly suppressed specific anti-BSA antibody production after secondary and tertiary immunization with the same antigen. Exposure to the SW procedure during primary immunization with BSA enhanced the specific antibody level after secondary immunization, while exposure to the apparatus alone did not influence the development of either the primary or secondary humoral immune response to BSA. Both ES-i...nduced suppression and SW-induced potentiation of the humoral immune response were partially inhibited by prior treatment with the opioid receptor antagonist naloxone. Additionally, treatments with the opioid peptides methionine- and leucine-enkephalin decreased anti-BSA antibody level, mimicking to some extent the effects of ES. It is suggested that ES and endogenous opioid peptides had long-term effects on humoral immunity through mechanisms involving immunologic memory.
Кључне речи:
antibodies / apparatus control / electric shock stress / opioid peptides / stress witnessingИзвор:
Stress-The International Journal on the Biology of Stress, 2003, 6, 4, 247-258Издавач:
- Taylor & Francis Ltd, Abingdon
DOI: 10.1080/1025389032000114515
ISSN: 1025-3890
PubMed: 14660057
WoS: 000188356000002
Scopus: 2-s2.0-1642556841
Институција/група
TorlakTY - JOUR AU - Stanojević, Stanislava AU - Dimitrijević, Mirjana AU - Kovačević-Jovanović, Vesna AU - Miletić, Tatjana AU - Vujić, Vesna AU - Radulović, Jelena PY - 2003 UR - http://intor.torlakinstitut.com/handle/123456789/165 AB - The effect of unpredictable, inescapable and uncontrollable electric tail shocks (ES) on the humoral immune response to bovine serum albumin (BSA) was investigated in the rat. Contributions of the procedures that accompany shock delivery, such as witnessing the ES procedure (stress witnessing, SW) and exposure to the apparatus for shock delivery (apparatus control, AC) to the changes in specific immunity induced by ES were also tested. All procedures were applied during primary and/or secondary immunization. It was demonstrated that exposure to ES during primary immunization with BSA significantly suppressed specific anti-BSA antibody production after secondary and tertiary immunization with the same antigen. Exposure to the SW procedure during primary immunization with BSA enhanced the specific antibody level after secondary immunization, while exposure to the apparatus alone did not influence the development of either the primary or secondary humoral immune response to BSA. Both ES-induced suppression and SW-induced potentiation of the humoral immune response were partially inhibited by prior treatment with the opioid receptor antagonist naloxone. Additionally, treatments with the opioid peptides methionine- and leucine-enkephalin decreased anti-BSA antibody level, mimicking to some extent the effects of ES. It is suggested that ES and endogenous opioid peptides had long-term effects on humoral immunity through mechanisms involving immunologic memory. PB - Taylor & Francis Ltd, Abingdon T2 - Stress-The International Journal on the Biology of Stress T1 - Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides EP - 258 IS - 4 SP - 247 VL - 6 DO - 10.1080/1025389032000114515 ER -
@article{ author = "Stanojević, Stanislava and Dimitrijević, Mirjana and Kovačević-Jovanović, Vesna and Miletić, Tatjana and Vujić, Vesna and Radulović, Jelena", year = "2003", abstract = "The effect of unpredictable, inescapable and uncontrollable electric tail shocks (ES) on the humoral immune response to bovine serum albumin (BSA) was investigated in the rat. Contributions of the procedures that accompany shock delivery, such as witnessing the ES procedure (stress witnessing, SW) and exposure to the apparatus for shock delivery (apparatus control, AC) to the changes in specific immunity induced by ES were also tested. All procedures were applied during primary and/or secondary immunization. It was demonstrated that exposure to ES during primary immunization with BSA significantly suppressed specific anti-BSA antibody production after secondary and tertiary immunization with the same antigen. Exposure to the SW procedure during primary immunization with BSA enhanced the specific antibody level after secondary immunization, while exposure to the apparatus alone did not influence the development of either the primary or secondary humoral immune response to BSA. Both ES-induced suppression and SW-induced potentiation of the humoral immune response were partially inhibited by prior treatment with the opioid receptor antagonist naloxone. Additionally, treatments with the opioid peptides methionine- and leucine-enkephalin decreased anti-BSA antibody level, mimicking to some extent the effects of ES. It is suggested that ES and endogenous opioid peptides had long-term effects on humoral immunity through mechanisms involving immunologic memory.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Stress-The International Journal on the Biology of Stress", title = "Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides", pages = "258-247", number = "4", volume = "6", doi = "10.1080/1025389032000114515" }
Stanojević, S., Dimitrijević, M., Kovačević-Jovanović, V., Miletić, T., Vujić, V.,& Radulović, J.. (2003). Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides. in Stress-The International Journal on the Biology of Stress Taylor & Francis Ltd, Abingdon., 6(4), 247-258. https://doi.org/10.1080/1025389032000114515
Stanojević S, Dimitrijević M, Kovačević-Jovanović V, Miletić T, Vujić V, Radulović J. Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides. in Stress-The International Journal on the Biology of Stress. 2003;6(4):247-258. doi:10.1080/1025389032000114515 .
Stanojević, Stanislava, Dimitrijević, Mirjana, Kovačević-Jovanović, Vesna, Miletić, Tatjana, Vujić, Vesna, Radulović, Jelena, "Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides" in Stress-The International Journal on the Biology of Stress, 6, no. 4 (2003):247-258, https://doi.org/10.1080/1025389032000114515 . .