Effects of beta-adrenoceptor blockade on the phenotypic characteristics of thymocytes and peripheral blood lymphocytes
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2003
Authors
Rauški, AleksandraKosec, Duško
Vidić-Danković, Biljana
Plećaš-Solarović, Bosiljka
Leposavić, Gordana
Article (Published version)
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The study revealed that beta-adrenoceptor blockade with propranolol (0.40 mg/100 g/day, s.c.) in adult male DA rats: (i) increased the thymocyte proliferation and apoptosis, (ii) caused disturbances in kinetics of T cell differentiation leading to distinguishable changes in relative proportion of thymocytes at distinct maturational steps and to an expansion of the most mature single positive (CD4+, CD8+) thymocyte pool, (iii) affected the relative proportion of neither CD4+ nor CD8+ peripheral blood lymphocytes (PBL), and (iv) augmented the relative number of CD8+CD25+ cells. Thus, the results suggest the role of beta-adrenoceptors in fine-tuning of T cell maturation, and, possibly, distribution and activation of distinct PBL subsets.
Keywords:
beta-adrenoceptor blockade / peripheral T-cell phenotype / thymocyte apoptosis / thymocyte differentiation / thymocyte proliferationSource:
International Journal of Neuroscience, 2003, 113, 12, 1653-1673Publisher:
- Taylor & Francis Ltd, Abingdon
DOI: 10.1080/00207450390245216
ISSN: 0020-7454
PubMed: 14602539
WoS: 000186897000002
Scopus: 2-s2.0-10744222299
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TorlakTY - JOUR AU - Rauški, Aleksandra AU - Kosec, Duško AU - Vidić-Danković, Biljana AU - Plećaš-Solarović, Bosiljka AU - Leposavić, Gordana PY - 2003 UR - http://intor.torlakinstitut.com/handle/123456789/162 AB - The study revealed that beta-adrenoceptor blockade with propranolol (0.40 mg/100 g/day, s.c.) in adult male DA rats: (i) increased the thymocyte proliferation and apoptosis, (ii) caused disturbances in kinetics of T cell differentiation leading to distinguishable changes in relative proportion of thymocytes at distinct maturational steps and to an expansion of the most mature single positive (CD4+, CD8+) thymocyte pool, (iii) affected the relative proportion of neither CD4+ nor CD8+ peripheral blood lymphocytes (PBL), and (iv) augmented the relative number of CD8+CD25+ cells. Thus, the results suggest the role of beta-adrenoceptors in fine-tuning of T cell maturation, and, possibly, distribution and activation of distinct PBL subsets. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Effects of beta-adrenoceptor blockade on the phenotypic characteristics of thymocytes and peripheral blood lymphocytes EP - 1673 IS - 12 SP - 1653 VL - 113 DO - 10.1080/00207450390245216 ER -
@article{ author = "Rauški, Aleksandra and Kosec, Duško and Vidić-Danković, Biljana and Plećaš-Solarović, Bosiljka and Leposavić, Gordana", year = "2003", abstract = "The study revealed that beta-adrenoceptor blockade with propranolol (0.40 mg/100 g/day, s.c.) in adult male DA rats: (i) increased the thymocyte proliferation and apoptosis, (ii) caused disturbances in kinetics of T cell differentiation leading to distinguishable changes in relative proportion of thymocytes at distinct maturational steps and to an expansion of the most mature single positive (CD4+, CD8+) thymocyte pool, (iii) affected the relative proportion of neither CD4+ nor CD8+ peripheral blood lymphocytes (PBL), and (iv) augmented the relative number of CD8+CD25+ cells. Thus, the results suggest the role of beta-adrenoceptors in fine-tuning of T cell maturation, and, possibly, distribution and activation of distinct PBL subsets.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Effects of beta-adrenoceptor blockade on the phenotypic characteristics of thymocytes and peripheral blood lymphocytes", pages = "1673-1653", number = "12", volume = "113", doi = "10.1080/00207450390245216" }
Rauški, A., Kosec, D., Vidić-Danković, B., Plećaš-Solarović, B.,& Leposavić, G.. (2003). Effects of beta-adrenoceptor blockade on the phenotypic characteristics of thymocytes and peripheral blood lymphocytes. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 113(12), 1653-1673. https://doi.org/10.1080/00207450390245216
Rauški A, Kosec D, Vidić-Danković B, Plećaš-Solarović B, Leposavić G. Effects of beta-adrenoceptor blockade on the phenotypic characteristics of thymocytes and peripheral blood lymphocytes. in International Journal of Neuroscience. 2003;113(12):1653-1673. doi:10.1080/00207450390245216 .
Rauški, Aleksandra, Kosec, Duško, Vidić-Danković, Biljana, Plećaš-Solarović, Bosiljka, Leposavić, Gordana, "Effects of beta-adrenoceptor blockade on the phenotypic characteristics of thymocytes and peripheral blood lymphocytes" in International Journal of Neuroscience, 113, no. 12 (2003):1653-1673, https://doi.org/10.1080/00207450390245216 . .