InTOR - Repository of the Institute “Torlak”
Institute of Virology, Vaccines and Sera “Torlak”
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   InTOR
  • Torlak
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   InTOR
  • Torlak
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age

Authorized Users Only
2002
Authors
Leposavić, Gordana
Pejčić-Karapetrović, Branka
Kosec, Duško
Article (Published version)
Metadata
Show full item record
Abstract
In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping of thymus size and intrathymic T cell Maturation, In 4-month-old control rats the thymus size and cellularity returned to the corresponding levels in 1-month-old rats, These levels were sustained during the following 6 months. In spite of that, the distribution of the main thymocyte subsets in these rats as Subjected to significant changes, probably due to an age-associated diminishing thymus ability to provide efficient T cell differentiation. The results added further v.,eight to a potential feedback regulatory role of CD4+8- cells in thymopoiesis. Furthermore. they revealed that the orchidectomy-induced (i) enlargement of the thymus size and enrichment of the thymic ly...mphoid cell content are of a limited duration and (ii) alterations in the relative proportion of thymocytes become quantitatively more pronounced with duration of the gonadal deprivation. Thus, the study also indicates that the age-associated changes in gonadal hormones may be, at least partly. responsible For the age-related reshaping a of the T cell maturation sequence, and hence for remodeling T cell dependent immune functions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Keywords:
thymus / T cell differentiation / castration / androgens
Source:
Mechanisms of Ageing and Development, 2002, 123, 4, 401-411
Publisher:
  • Elsevier Ireland Ltd, Clare

DOI: 10.1016/S0047-6374(01)00399-2

ISSN: 0047-6374

PubMed: 11744050

WoS: 000177125000013

Scopus: 2-s2.0-0036138232
[ Google Scholar ]
8
7
URI
http://intor.torlakinstitut.com/handle/123456789/142
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - JOUR
AU  - Leposavić, Gordana
AU  - Pejčić-Karapetrović, Branka
AU  - Kosec, Duško
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/142
AB  - In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping of thymus size and intrathymic T cell Maturation, In 4-month-old control rats the thymus size and cellularity returned to the corresponding levels in 1-month-old rats, These levels were sustained during the following 6 months. In spite of that, the distribution of the main thymocyte subsets in these rats as Subjected to significant changes, probably due to an age-associated diminishing thymus ability to provide efficient T cell differentiation. The results added further v.,eight to a potential feedback regulatory role of CD4+8- cells in thymopoiesis. Furthermore. they revealed that the orchidectomy-induced (i) enlargement of the thymus size and enrichment of the thymic lymphoid cell content are of a limited duration and (ii) alterations in the relative proportion of thymocytes become quantitatively more pronounced with duration of the gonadal deprivation. Thus, the study also indicates that the age-associated changes in gonadal hormones may be, at least partly. responsible For the age-related reshaping a of the T cell maturation sequence, and hence for remodeling T cell dependent immune functions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
PB  - Elsevier Ireland Ltd, Clare
T2  - Mechanisms of Ageing and Development
T1  - Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age
EP  - 411
IS  - 4
SP  - 401
VL  - 123
DO  - 10.1016/S0047-6374(01)00399-2
UR  - conv_130
ER  - 
@article{
author = "Leposavić, Gordana and Pejčić-Karapetrović, Branka and Kosec, Duško",
year = "2002",
abstract = "In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping of thymus size and intrathymic T cell Maturation, In 4-month-old control rats the thymus size and cellularity returned to the corresponding levels in 1-month-old rats, These levels were sustained during the following 6 months. In spite of that, the distribution of the main thymocyte subsets in these rats as Subjected to significant changes, probably due to an age-associated diminishing thymus ability to provide efficient T cell differentiation. The results added further v.,eight to a potential feedback regulatory role of CD4+8- cells in thymopoiesis. Furthermore. they revealed that the orchidectomy-induced (i) enlargement of the thymus size and enrichment of the thymic lymphoid cell content are of a limited duration and (ii) alterations in the relative proportion of thymocytes become quantitatively more pronounced with duration of the gonadal deprivation. Thus, the study also indicates that the age-associated changes in gonadal hormones may be, at least partly. responsible For the age-related reshaping a of the T cell maturation sequence, and hence for remodeling T cell dependent immune functions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Mechanisms of Ageing and Development",
title = "Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age",
pages = "411-401",
number = "4",
volume = "123",
doi = "10.1016/S0047-6374(01)00399-2",
url = "conv_130"
}
Leposavić, G., Pejčić-Karapetrović, B.,& Kosec, D.. (2002). Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age. in Mechanisms of Ageing and Development
Elsevier Ireland Ltd, Clare., 123(4), 401-411.
https://doi.org/10.1016/S0047-6374(01)00399-2
conv_130
Leposavić G, Pejčić-Karapetrović B, Kosec D. Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age. in Mechanisms of Ageing and Development. 2002;123(4):401-411.
doi:10.1016/S0047-6374(01)00399-2
conv_130 .
Leposavić, Gordana, Pejčić-Karapetrović, Branka, Kosec, Duško, "Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age" in Mechanisms of Ageing and Development, 123, no. 4 (2002):401-411,
https://doi.org/10.1016/S0047-6374(01)00399-2 .,
conv_130 .

DSpace software copyright © 2002-2015  DuraSpace
About InTOR | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About InTOR | Send Feedback

OpenAIRERCUB