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Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis

Authorized Users Only
2002
Authors
Popović, N.
Popović, M.
Jovanova-Nešić, Katica
Bokonjić, D.
Kostić, V.S.
Šternić, N.
Rakić, L.
Article (Published version)
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Abstract
Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p lt .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p lt .001) increase in the number of shocks delive...red before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.

Keywords:
learned helplessness / neural transplantation / nucleus basalis / magnocellularis / rat
Source:
International Journal of Neuroscience, 2002, 112, 1, 105-115
Publisher:
  • Taylor & Francis Ltd, Abingdon

DOI: 10.1080/00207450212017

ISSN: 0020-7454

PubMed: 12152402

WoS: 000175942100008

Scopus: 2-s2.0-0035991040
[ Google Scholar ]
3
2
URI
http://intor.torlakinstitut.com/handle/123456789/136
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - JOUR
AU  - Popović, N.
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Bokonjić, D.
AU  - Kostić, V.S.
AU  - Šternić, N.
AU  - Rakić, L.
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/136
AB  - Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p  lt  .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p  lt  .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis
EP  - 115
IS  - 1
SP  - 105
VL  - 112
DO  - 10.1080/00207450212017
UR  - conv_128
ER  - 
@article{
author = "Popović, N. and Popović, M. and Jovanova-Nešić, Katica and Bokonjić, D. and Kostić, V.S. and Šternić, N. and Rakić, L.",
year = "2002",
abstract = "Recent data of our group have shown that bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) in rats reduced the escape behavior deficit that occurs in the learned helplessness test. The present study was done to establish the effect of intracerebral neural transplantation on the change in escape behavior of NBM-lesioned adult male Wistar rats in the learned helplessness test. At 2 days (NBM-ET) or 10 days (NBM-DT) after bilateral electrolytic NBM-lesions, small fragments of fetal frontal cortex (18th day of gestation) were allotransplanted into the lesioned NBM. Ten days after neural transplantation, the learned helplessness test was performed. The number of shocks that animals received before making an escape response was significantly reduced in NBM-lesioned rats (p  lt  .001, compared to intact control and sham-operated rats). In comparison to NBM-lesioned and sham-ET rats, the NBM-ET rats showed a marked (p  lt  .001) increase in the number of shocks delivered before the animal made such an escape response. On the other hand, NBM-DT rats did not show this increase. These results indicate that neural transplantation performed at an early time after lesioning of NBM reversed the effect of this lesion in rats exposed to learned helplessness test.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis",
pages = "115-105",
number = "1",
volume = "112",
doi = "10.1080/00207450212017",
url = "conv_128"
}
Popović, N., Popović, M., Jovanova-Nešić, K., Bokonjić, D., Kostić, V.S., Šternić, N.,& Rakić, L.. (2002). Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 112(1), 105-115.
https://doi.org/10.1080/00207450212017
conv_128
Popović N, Popović M, Jovanova-Nešić K, Bokonjić D, Kostić V, Šternić N, Rakić L. Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis. in International Journal of Neuroscience. 2002;112(1):105-115.
doi:10.1080/00207450212017
conv_128 .
Popović, N., Popović, M., Jovanova-Nešić, Katica, Bokonjić, D., Kostić, V.S., Šternić, N., Rakić, L., "Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis" in International Journal of Neuroscience, 112, no. 1 (2002):105-115,
https://doi.org/10.1080/00207450212017 .,
conv_128 .

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