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In vivo modulation of the distribution of thymocyte subsets by female sex steroid hormones
dc.creator | Leposavić, Gordana | |
dc.creator | Obradović, S. | |
dc.creator | Kosec, Duško | |
dc.creator | Pejčić-Karapetrović, Branka | |
dc.creator | Vidić-Danković, Biljana | |
dc.date.accessioned | 2021-02-18T10:23:29Z | |
dc.date.available | 2021-02-18T10:23:29Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 1567-5769 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/129 | |
dc.description.abstract | This study examined the effects of the principal ovarian steroids, 17β-estradiol (E) and progesterone (P), on the thymic structure and on the intrathymic development of T-cells. Adult female rats were ovariectomized (OVX) and treated for 14 days with physiological doses of either E or P; controls received an equivalent volume of vehicle. Ovariectomy produced a marked increase (vs. sham-operated controls) in thymus weight, which was associated with an increase in the volume and cellularity of both the medulla and cortex. Treatment of OVX rats with E reduced the thymic weight to value, which was significantly lower than that of sham-operated controls decreasing the volume of cortex below level in sham-OVX rats, and reversing the effect of ovariectomy on the volume of medulla. P only prevented the increases in thymus weight and cortical volume induced by OVX. However, unlike E, it had no discernable effect on the medullary volume. E treatment reduced the cellularity of the cortex and medulla to values, which were lower than those of sham-OVX rats, while P only reversed the effects of OVX on the cellularity of both the compartments. Ovariectomy also had a profound effect on the thymocyte profile, increasing the proportion of CD4 + 8 + TCRαβ - cells and producing a corresponding decrease in the relative proportions of all TCR αβ high cell subsets. The decrease in the latter was opposed by treatment with E or P. However, the sensitivity of the less mature cells (except CD4 - 8 - TCR αβ - , the percentage of which was reduced by both hormones) to the two hormones differed. E reduced the relative proportion of CD4 - 8 + TCRαβ - , CD4 - 8 + TCRαβ low and CD4 + 8 + TCRαβ - cells, while P increased the percentage of CD4 - 8 + TCRαβ low cells. The results suggest that E and P affect both the lymphoid and nonlymphoid compartments of the thymus, and that while P increases the volume of the nonlymphoid component of the medulla, E has the opposite effect. The finding that ovariectomy decreased while E and P increased the relative proportion of the most mature thymocytes, which include CD4 - 8 - TCRαβ high cells that are believed to harbour potentially autoreactive cell clones, is particularly interesting and may relate to the high propensity of autoimmune diseases in females. | en |
dc.publisher | Elsevier | |
dc.rights | restrictedAccess | |
dc.source | International Immunopharmacology | |
dc.subject | Estrogens | en |
dc.subject | Ovariectomy | en |
dc.subject | Progesterone | en |
dc.subject | Rat thymus | en |
dc.subject | T-cell maturation | en |
dc.title | In vivo modulation of the distribution of thymocyte subsets by female sex steroid hormones | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 12 | |
dc.citation.issue | 1 | |
dc.citation.other | 1(1): 1-12 | |
dc.citation.rank | M23 | |
dc.citation.spage | 1 | |
dc.citation.volume | 1 | |
dc.identifier.doi | 10.1016/S1567-5769(00)00006-0 | |
dc.identifier.pmid | 11367507 | |
dc.identifier.scopus | 2-s2.0-0035127781 | |
dc.identifier.wos | 000168328700001 | |
dc.type.version | publishedVersion |