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dc.creatorLeposavić, Gordana
dc.creatorObradović, S.
dc.creatorKosec, Duško
dc.creatorPejčić-Karapetrović, Branka
dc.creatorVidić-Danković, Biljana
dc.date.accessioned2021-02-18T10:23:29Z
dc.date.available2021-02-18T10:23:29Z
dc.date.issued2001
dc.identifier.issn1567-5769
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/129
dc.description.abstractThis study examined the effects of the principal ovarian steroids, 17β-estradiol (E) and progesterone (P), on the thymic structure and on the intrathymic development of T-cells. Adult female rats were ovariectomized (OVX) and treated for 14 days with physiological doses of either E or P; controls received an equivalent volume of vehicle. Ovariectomy produced a marked increase (vs. sham-operated controls) in thymus weight, which was associated with an increase in the volume and cellularity of both the medulla and cortex. Treatment of OVX rats with E reduced the thymic weight to value, which was significantly lower than that of sham-operated controls decreasing the volume of cortex below level in sham-OVX rats, and reversing the effect of ovariectomy on the volume of medulla. P only prevented the increases in thymus weight and cortical volume induced by OVX. However, unlike E, it had no discernable effect on the medullary volume. E treatment reduced the cellularity of the cortex and medulla to values, which were lower than those of sham-OVX rats, while P only reversed the effects of OVX on the cellularity of both the compartments. Ovariectomy also had a profound effect on the thymocyte profile, increasing the proportion of CD4 + 8 + TCRαβ - cells and producing a corresponding decrease in the relative proportions of all TCR αβ high cell subsets. The decrease in the latter was opposed by treatment with E or P. However, the sensitivity of the less mature cells (except CD4 - 8 - TCR αβ - , the percentage of which was reduced by both hormones) to the two hormones differed. E reduced the relative proportion of CD4 - 8 + TCRαβ - , CD4 - 8 + TCRαβ low and CD4 + 8 + TCRαβ - cells, while P increased the percentage of CD4 - 8 + TCRαβ low cells. The results suggest that E and P affect both the lymphoid and nonlymphoid compartments of the thymus, and that while P increases the volume of the nonlymphoid component of the medulla, E has the opposite effect. The finding that ovariectomy decreased while E and P increased the relative proportion of the most mature thymocytes, which include CD4 - 8 - TCRαβ high cells that are believed to harbour potentially autoreactive cell clones, is particularly interesting and may relate to the high propensity of autoimmune diseases in females.en
dc.publisherElsevier
dc.rightsrestrictedAccess
dc.sourceInternational Immunopharmacology
dc.subjectEstrogensen
dc.subjectOvariectomyen
dc.subjectProgesteroneen
dc.subjectRat thymusen
dc.subjectT-cell maturationen
dc.titleIn vivo modulation of the distribution of thymocyte subsets by female sex steroid hormonesen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage12
dc.citation.issue1
dc.citation.other1(1): 1-12
dc.citation.rankM23
dc.citation.spage1
dc.citation.volume1
dc.identifier.doi10.1016/S1567-5769(00)00006-0
dc.identifier.pmid11367507
dc.identifier.scopus2-s2.0-0035127781
dc.identifier.wos000168328700001
dc.type.versionpublishedVersion


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