Behavior and severity of adjuvant arthritis in four rat strains
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2001
Authors
Dimitrijević, MirjanaLaban, Olgica
Đurić, V.J.
Stanojević, Stanislava
Miletić, Tatjana
Kovačević-Jovanović, Vesna
Todorović, C.
Radulović, Jelena
Article (Published version)
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Previous research has suggested that behavioral traits of the histocompatible Lewis and Fischer strains of rats could be related to the difference in their susceptibility to adjuvant arthritis (AA), In the present study, the predictive value of behavioral markers in susceptibility to AA was investigated in nonhistocompatible inbred DA, Lewis, Albino Oxford (AO), and outbred Wistar strain. Behavioral profiles (open filed test and forced swim test) were determined prior to immunization with a single intradermal injection of complete Freund's adjuvant. Animals were daily scored for clinical signs of AA. The occurrence of certain behaviors and clinical indices of AA was significantly associated with strain membership. Discriminant analysis identified strain-related behavioral and illness profiles with very few overlaps among the phenotypes. Discriminant classification significantly exceeded the proportion of cases, which could have been correctly classified on the basis of chance. Open fie...ld behavior, in particular, exploration and grooming, differentiated among AA-susceptible and AA-resistant strains. Multiple regression analysis indicated that severity of AA (maximum clinical sign) can be predicted by the latency time and grooming behavior in the open field independently of strain membership. No clear distinction between AA-susceptible and AA-resistant strains was found with respect to forced swim test immobility. It was concluded that (a) strain-related genetic predisposition is important for the expression of certain behavioral traits and for susceptibility to AA and (b) open field behaviors, particularly grooming and latency, predict susceptibility to AA across different rat strains. (C) 2001 Academic Press.
Keywords:
adjuvant arthritis / open field test / forced swim test / rat / genetic differencesSource:
Brain Behavior and Immunity, 2001, 15, 3, 255-265Publisher:
- Academic Press Inc, San Diego
DOI: 10.1006/brbi.2000.0599
ISSN: 0889-1591
PubMed: 11566049
WoS: 000170896400004
Scopus: 2-s2.0-0035166002
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TorlakTY - JOUR AU - Dimitrijević, Mirjana AU - Laban, Olgica AU - Đurić, V.J. AU - Stanojević, Stanislava AU - Miletić, Tatjana AU - Kovačević-Jovanović, Vesna AU - Todorović, C. AU - Radulović, Jelena PY - 2001 UR - http://intor.torlakinstitut.com/handle/123456789/128 AB - Previous research has suggested that behavioral traits of the histocompatible Lewis and Fischer strains of rats could be related to the difference in their susceptibility to adjuvant arthritis (AA), In the present study, the predictive value of behavioral markers in susceptibility to AA was investigated in nonhistocompatible inbred DA, Lewis, Albino Oxford (AO), and outbred Wistar strain. Behavioral profiles (open filed test and forced swim test) were determined prior to immunization with a single intradermal injection of complete Freund's adjuvant. Animals were daily scored for clinical signs of AA. The occurrence of certain behaviors and clinical indices of AA was significantly associated with strain membership. Discriminant analysis identified strain-related behavioral and illness profiles with very few overlaps among the phenotypes. Discriminant classification significantly exceeded the proportion of cases, which could have been correctly classified on the basis of chance. Open field behavior, in particular, exploration and grooming, differentiated among AA-susceptible and AA-resistant strains. Multiple regression analysis indicated that severity of AA (maximum clinical sign) can be predicted by the latency time and grooming behavior in the open field independently of strain membership. No clear distinction between AA-susceptible and AA-resistant strains was found with respect to forced swim test immobility. It was concluded that (a) strain-related genetic predisposition is important for the expression of certain behavioral traits and for susceptibility to AA and (b) open field behaviors, particularly grooming and latency, predict susceptibility to AA across different rat strains. (C) 2001 Academic Press. PB - Academic Press Inc, San Diego T2 - Brain Behavior and Immunity T1 - Behavior and severity of adjuvant arthritis in four rat strains EP - 265 IS - 3 SP - 255 VL - 15 DO - 10.1006/brbi.2000.0599 ER -
@article{ author = "Dimitrijević, Mirjana and Laban, Olgica and Đurić, V.J. and Stanojević, Stanislava and Miletić, Tatjana and Kovačević-Jovanović, Vesna and Todorović, C. and Radulović, Jelena", year = "2001", abstract = "Previous research has suggested that behavioral traits of the histocompatible Lewis and Fischer strains of rats could be related to the difference in their susceptibility to adjuvant arthritis (AA), In the present study, the predictive value of behavioral markers in susceptibility to AA was investigated in nonhistocompatible inbred DA, Lewis, Albino Oxford (AO), and outbred Wistar strain. Behavioral profiles (open filed test and forced swim test) were determined prior to immunization with a single intradermal injection of complete Freund's adjuvant. Animals were daily scored for clinical signs of AA. The occurrence of certain behaviors and clinical indices of AA was significantly associated with strain membership. Discriminant analysis identified strain-related behavioral and illness profiles with very few overlaps among the phenotypes. Discriminant classification significantly exceeded the proportion of cases, which could have been correctly classified on the basis of chance. Open field behavior, in particular, exploration and grooming, differentiated among AA-susceptible and AA-resistant strains. Multiple regression analysis indicated that severity of AA (maximum clinical sign) can be predicted by the latency time and grooming behavior in the open field independently of strain membership. No clear distinction between AA-susceptible and AA-resistant strains was found with respect to forced swim test immobility. It was concluded that (a) strain-related genetic predisposition is important for the expression of certain behavioral traits and for susceptibility to AA and (b) open field behaviors, particularly grooming and latency, predict susceptibility to AA across different rat strains. (C) 2001 Academic Press.", publisher = "Academic Press Inc, San Diego", journal = "Brain Behavior and Immunity", title = "Behavior and severity of adjuvant arthritis in four rat strains", pages = "265-255", number = "3", volume = "15", doi = "10.1006/brbi.2000.0599" }
Dimitrijević, M., Laban, O., Đurić, V.J., Stanojević, S., Miletić, T., Kovačević-Jovanović, V., Todorović, C.,& Radulović, J.. (2001). Behavior and severity of adjuvant arthritis in four rat strains. in Brain Behavior and Immunity Academic Press Inc, San Diego., 15(3), 255-265. https://doi.org/10.1006/brbi.2000.0599
Dimitrijević M, Laban O, Đurić V, Stanojević S, Miletić T, Kovačević-Jovanović V, Todorović C, Radulović J. Behavior and severity of adjuvant arthritis in four rat strains. in Brain Behavior and Immunity. 2001;15(3):255-265. doi:10.1006/brbi.2000.0599 .
Dimitrijević, Mirjana, Laban, Olgica, Đurić, V.J., Stanojević, Stanislava, Miletić, Tatjana, Kovačević-Jovanović, Vesna, Todorović, C., Radulović, Jelena, "Behavior and severity of adjuvant arthritis in four rat strains" in Brain Behavior and Immunity, 15, no. 3 (2001):255-265, https://doi.org/10.1006/brbi.2000.0599 . .