Приказ основних података о документу
Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen
Indukcija i reindukcija eksperimentalnog alergijskog encefalomijelitisa u DA pacova - uticaj starosti i encefalitogena
dc.creator | Dimitrijević, Mirjana | |
dc.creator | Laban, Olgica | |
dc.creator | Stanojević, Stanislava | |
dc.creator | Radulović, Jelena | |
dc.date.accessioned | 2021-02-18T10:22:41Z | |
dc.date.available | 2021-02-18T10:22:41Z | |
dc.date.issued | 2000 | |
dc.identifier.issn | 0567-8315 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/117 | |
dc.description.abstract | Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week- old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats. | en |
dc.description.abstract | U radu su prikazani rezultati ispitivanja osetljivosti na indukciju i reindukciju eksperimentalnog alergijskog encefalomojelitisa (EAE) u DA pacova, oba pola, starosti 5,8 i 27 nedelja. Za imunizaciju su korišćeni homogenati kičmene moždine zamorca (KMZ) ili kičmene moždine Lewis pacova (KMP) u kompletnom Freund-ovom adjuvansu. Rezultati su pokazali da: a) pol ne utiče na razvoj EAE-a u 5 i 8 nedelja starih DA pacova; b) osetljivost na EAE raste sa starošću; c) KMP je jači encefalitogen od KMZ; d) produkcija anti-mijelin bazni protein (MBP) antitela je veća nakon imunizacije sa KMZ nego sa KMP; e) nivo anti-MBP antitela nije u korelaciji sa kliničkim znakom EAE-a; f) reindukcija EAE-a je moguća u pacova starih 27 nedelja ako se za indukciju i/ili reindukciju koristi KMP; i g) anti-MBP antitela nisu odgovorna za rezistenciju na reindukciju EAE-a u DA pacova. | sr |
dc.publisher | Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd | |
dc.rights | openAccess | |
dc.source | Acta veterinaria - Beograd | |
dc.subject | experimental allergic encephalomyelitis | en |
dc.subject | DA rats | en |
dc.subject | anti-myelin basic protein antibodies | en |
dc.title | Induction and reinduction of experimental allergic encephalomyelitis in DA rats: The effect of age and encephalitogen | en |
dc.title | Indukcija i reindukcija eksperimentalnog alergijskog encefalomijelitisa u DA pacova - uticaj starosti i encefalitogena | sr |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 296 | |
dc.citation.issue | 5-6 | |
dc.citation.other | 50(5-6): 289-296 | |
dc.citation.rank | M23 | |
dc.citation.spage | 289 | |
dc.citation.volume | 50 | |
dc.identifier.fulltext | http://intor.torlakinstitut.com/bitstream/id/12/114.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_intor_117 | |
dc.identifier.wos | 000166742700003 | |
dc.type.version | publishedVersion |