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Peripheral effects of methionine-enkephalin on inflammatory reactions and behavior in the rat
dc.creator | Vujić-Redžić, V. | |
dc.creator | Dimitrijević, Mirjana | |
dc.creator | Stanojević, Stanislava | |
dc.creator | Kovačević-Jovanović, Vesna | |
dc.creator | Miletić, Tatjana | |
dc.creator | Radulović, Jelena | |
dc.date.accessioned | 2021-02-18T10:22:34Z | |
dc.date.available | 2021-02-18T10:22:34Z | |
dc.date.issued | 2000 | |
dc.identifier.issn | 1021-7401 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/115 | |
dc.description.abstract | Methionine-enkephalin (Met-Enk) induces notable alterations in immune and central nervous system functions. The present study was conducted in order to compare peripheral and central effects of Met-Enk on nonspecific immunity, open field behavior and pain perception in the rat. The results showed that 0.2 mg/kg of Met-Enk given intraperitoneally (i.p.) increased concanavalin A (Con-A)-induced paw edema and enhanced basal and phorbol myristate acetate (PMA)-stimulated H2O2 production of peritoneal macrophages. Met-Enk-induced immunopotentiation was antagonized by anti-Met-Enk antibodies (anti-Met-Enk-Ig) and quaternary naltrexone (qNtx). Met-Enk injected i.p. produced an increase of horizontal and vertical locomotor activity in the open field that was reversed by i.p. administration of anti-Met-Enk-Ig and qNtx. The dose of 0.2 mg/kg of Met-Enk applied i.p. did not affect the number of writhes in the test of analgesia. Intracerebroventricular (i.c.v.) injection of Met-Enk, given in a dose that was previously shown to be immunostimulatory, enhanced only basal H2O2 production of peritoneal macrophages, and anti-Met-Enk-Ig antagonized this effect. Besides, i.c.v. treatment with anti-Met-Enk-Ig increased and decreased H2O2 production of peritoneal macrophages under basal and stimulated conditions, respectively, Met-Enk and anti-Met-Enk-Ig injected i.c.v. did not influence activity in the open field and pain sensitivity. Thus, the i.c.v. dose of Met-Enk that was sufficient to modulate immune functions did not influence behavior. It may be concluded that Met-Enk modulated nonspecific immune responses and open field behavior by peripheral mechanisms. Copyright (C) 2000 S. Karger AG, Basel. | en |
dc.publisher | Karger, Basel | |
dc.rights | restrictedAccess | |
dc.source | Neuroimmunomodulation | |
dc.subject | methionine-enkephalin | en |
dc.subject | anti-methionine-enkephalin | en |
dc.subject | antibodies | en |
dc.subject | paw edema | en |
dc.subject | peritoneal macrophages | en |
dc.subject | H2O2 release | en |
dc.subject | behavior | en |
dc.subject | rat | en |
dc.title | Peripheral effects of methionine-enkephalin on inflammatory reactions and behavior in the rat | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 77 | |
dc.citation.issue | 2 | |
dc.citation.other | 8(2): 70-77 | |
dc.citation.rank | M21 | |
dc.citation.spage | 70 | |
dc.citation.volume | 8 | |
dc.identifier.doi | 10.1159/000026455 | |
dc.identifier.pmid | 10965231 | |
dc.identifier.scopus | 2-s2.0-0033803297 | |
dc.identifier.wos | 000089014700003 | |
dc.type.version | publishedVersion |