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Peripheral effects of methionine-enkephalin on inflammatory reactions and behavior in the rat

Само за регистроване кориснике
2000
Аутори
Vujić-Redžić, V.
Dimitrijević, Mirjana
Stanojević, Stanislava
Kovačević-Jovanović, Vesna
Miletić, Tatjana
Radulović, Jelena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
Methionine-enkephalin (Met-Enk) induces notable alterations in immune and central nervous system functions. The present study was conducted in order to compare peripheral and central effects of Met-Enk on nonspecific immunity, open field behavior and pain perception in the rat. The results showed that 0.2 mg/kg of Met-Enk given intraperitoneally (i.p.) increased concanavalin A (Con-A)-induced paw edema and enhanced basal and phorbol myristate acetate (PMA)-stimulated H2O2 production of peritoneal macrophages. Met-Enk-induced immunopotentiation was antagonized by anti-Met-Enk antibodies (anti-Met-Enk-Ig) and quaternary naltrexone (qNtx). Met-Enk injected i.p. produced an increase of horizontal and vertical locomotor activity in the open field that was reversed by i.p. administration of anti-Met-Enk-Ig and qNtx. The dose of 0.2 mg/kg of Met-Enk applied i.p. did not affect the number of writhes in the test of analgesia. Intracerebroventricular (i.c.v.) injection of Met-Enk, given in a dos...e that was previously shown to be immunostimulatory, enhanced only basal H2O2 production of peritoneal macrophages, and anti-Met-Enk-Ig antagonized this effect. Besides, i.c.v. treatment with anti-Met-Enk-Ig increased and decreased H2O2 production of peritoneal macrophages under basal and stimulated conditions, respectively, Met-Enk and anti-Met-Enk-Ig injected i.c.v. did not influence activity in the open field and pain sensitivity. Thus, the i.c.v. dose of Met-Enk that was sufficient to modulate immune functions did not influence behavior. It may be concluded that Met-Enk modulated nonspecific immune responses and open field behavior by peripheral mechanisms. Copyright (C) 2000 S. Karger AG, Basel.

Кључне речи:
methionine-enkephalin / anti-methionine-enkephalin / antibodies / paw edema / peritoneal macrophages / H2O2 release / behavior / rat
Извор:
Neuroimmunomodulation, 2000, 8, 2, 70-77
Издавач:
  • Karger, Basel

DOI: 10.1159/000026455

ISSN: 1021-7401

PubMed: 10965231

WoS: 000089014700003

Scopus: 2-s2.0-0033803297
[ Google Scholar ]
12
12
URI
http://intor.torlakinstitut.com/handle/123456789/115
Колекције
  • Radovi istraživača / Researchers’ publications
Институција/група
Torlak
TY  - JOUR
AU  - Vujić-Redžić, V.
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Kovačević-Jovanović, Vesna
AU  - Miletić, Tatjana
AU  - Radulović, Jelena
PY  - 2000
UR  - http://intor.torlakinstitut.com/handle/123456789/115
AB  - Methionine-enkephalin (Met-Enk) induces notable alterations in immune and central nervous system functions. The present study was conducted in order to compare peripheral and central effects of Met-Enk on nonspecific immunity, open field behavior and pain perception in the rat. The results showed that 0.2 mg/kg of Met-Enk given intraperitoneally (i.p.) increased concanavalin A (Con-A)-induced paw edema and enhanced basal and phorbol myristate acetate (PMA)-stimulated H2O2 production of peritoneal macrophages. Met-Enk-induced immunopotentiation was antagonized by anti-Met-Enk antibodies (anti-Met-Enk-Ig) and quaternary naltrexone (qNtx). Met-Enk injected i.p. produced an increase of horizontal and vertical locomotor activity in the open field that was reversed by i.p. administration of anti-Met-Enk-Ig and qNtx. The dose of 0.2 mg/kg of Met-Enk applied i.p. did not affect the number of writhes in the test of analgesia. Intracerebroventricular (i.c.v.) injection of Met-Enk, given in a dose that was previously shown to be immunostimulatory, enhanced only basal H2O2 production of peritoneal macrophages, and anti-Met-Enk-Ig antagonized this effect. Besides, i.c.v. treatment with anti-Met-Enk-Ig increased and decreased H2O2 production of peritoneal macrophages under basal and stimulated conditions, respectively, Met-Enk and anti-Met-Enk-Ig injected i.c.v. did not influence activity in the open field and pain sensitivity. Thus, the i.c.v. dose of Met-Enk that was sufficient to modulate immune functions did not influence behavior. It may be concluded that Met-Enk modulated nonspecific immune responses and open field behavior by peripheral mechanisms. Copyright (C) 2000 S. Karger AG, Basel.
PB  - Karger, Basel
T2  - Neuroimmunomodulation
T1  - Peripheral effects of methionine-enkephalin on inflammatory reactions and behavior in the rat
EP  - 77
IS  - 2
SP  - 70
VL  - 8
DO  - 10.1159/000026455
UR  - conv_117
ER  - 
@article{
author = "Vujić-Redžić, V. and Dimitrijević, Mirjana and Stanojević, Stanislava and Kovačević-Jovanović, Vesna and Miletić, Tatjana and Radulović, Jelena",
year = "2000",
abstract = "Methionine-enkephalin (Met-Enk) induces notable alterations in immune and central nervous system functions. The present study was conducted in order to compare peripheral and central effects of Met-Enk on nonspecific immunity, open field behavior and pain perception in the rat. The results showed that 0.2 mg/kg of Met-Enk given intraperitoneally (i.p.) increased concanavalin A (Con-A)-induced paw edema and enhanced basal and phorbol myristate acetate (PMA)-stimulated H2O2 production of peritoneal macrophages. Met-Enk-induced immunopotentiation was antagonized by anti-Met-Enk antibodies (anti-Met-Enk-Ig) and quaternary naltrexone (qNtx). Met-Enk injected i.p. produced an increase of horizontal and vertical locomotor activity in the open field that was reversed by i.p. administration of anti-Met-Enk-Ig and qNtx. The dose of 0.2 mg/kg of Met-Enk applied i.p. did not affect the number of writhes in the test of analgesia. Intracerebroventricular (i.c.v.) injection of Met-Enk, given in a dose that was previously shown to be immunostimulatory, enhanced only basal H2O2 production of peritoneal macrophages, and anti-Met-Enk-Ig antagonized this effect. Besides, i.c.v. treatment with anti-Met-Enk-Ig increased and decreased H2O2 production of peritoneal macrophages under basal and stimulated conditions, respectively, Met-Enk and anti-Met-Enk-Ig injected i.c.v. did not influence activity in the open field and pain sensitivity. Thus, the i.c.v. dose of Met-Enk that was sufficient to modulate immune functions did not influence behavior. It may be concluded that Met-Enk modulated nonspecific immune responses and open field behavior by peripheral mechanisms. Copyright (C) 2000 S. Karger AG, Basel.",
publisher = "Karger, Basel",
journal = "Neuroimmunomodulation",
title = "Peripheral effects of methionine-enkephalin on inflammatory reactions and behavior in the rat",
pages = "77-70",
number = "2",
volume = "8",
doi = "10.1159/000026455",
url = "conv_117"
}
Vujić-Redžić, V., Dimitrijević, M., Stanojević, S., Kovačević-Jovanović, V., Miletić, T.,& Radulović, J.. (2000). Peripheral effects of methionine-enkephalin on inflammatory reactions and behavior in the rat. in Neuroimmunomodulation
Karger, Basel., 8(2), 70-77.
https://doi.org/10.1159/000026455
conv_117
Vujić-Redžić V, Dimitrijević M, Stanojević S, Kovačević-Jovanović V, Miletić T, Radulović J. Peripheral effects of methionine-enkephalin on inflammatory reactions and behavior in the rat. in Neuroimmunomodulation. 2000;8(2):70-77.
doi:10.1159/000026455
conv_117 .
Vujić-Redžić, V., Dimitrijević, Mirjana, Stanojević, Stanislava, Kovačević-Jovanović, Vesna, Miletić, Tatjana, Radulović, Jelena, "Peripheral effects of methionine-enkephalin on inflammatory reactions and behavior in the rat" in Neuroimmunomodulation, 8, no. 2 (2000):70-77,
https://doi.org/10.1159/000026455 .,
conv_117 .

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